Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Department of Functional Neurosurgery and Stereotaxy, Medical Faculty, University Hospital, Düsseldorf, Germany.
Neuroimage Clin. 2023;37:103317. doi: 10.1016/j.nicl.2023.103317. Epub 2023 Jan 4.
The implantation of deep brain stimulation (DBS) electrodes in Parkinson's disease (PD) patients can lead to a temporary improvement in motor symptoms, known as the stun effect. However, the network alterations induced by the stun effect are not well characterized. As therapeutic DBS is known to alter resting-state networks (RSN) and subsequent motor symptoms in patients with PD, we aimed to investigate whether the DBS-related stun effect also modulated RSNs. Therefore, we analyzed RSNs of 27 PD patients (8 females, 59.0 +- 8.7 years) using magnetoencephalography and compared them to RSNs of 24 age-matched healthy controls (8 females, 62.8 +- 5.1 years). We recorded 30 min of resting-state activity two days before and one day after implantation of the electrodes with and without dopaminergic medication. RSNs were determined by use of phase-amplitude coupling between a low frequency phase and a high gamma amplitude and examined for differences between conditions (i.e., pre vs post surgery). We identified four RSNs across all conditions: sensory-motor, visual, fronto-occipital, and frontal. Each RSN was altered due to electrode implantation. Importantly, these changes were not restricted to spatially close areas to the electrode trajectory. Interestingly, pre-operative RSNs corresponded better with healthy control RSNs regarding the spatial overlap, although the stun effect is associated with motor improvement. Our findings reveal that the stun effect induced by implantation of electrodes exerts brain wide changes in different functional RSNs.
脑深部电刺激（DBS）电极植入帕金森病（PD）患者可导致运动症状的暂时改善，即“电击效应”。然而，电击效应引起的网络改变尚未得到很好的描述。由于已知治疗性 DBS 会改变 PD 患者的静息态网络（RSN）和随后的运动症状，我们旨在研究 DBS 相关的电击效应是否也调节 RSN。因此，我们使用脑磁图分析了 27 名 PD 患者（8 名女性，59.0+-8.7 岁）的 RSN，并将其与 24 名年龄匹配的健康对照者（8 名女性，62.8+-5.1 岁）的 RSN 进行比较。我们在植入电极前后两天，在有无多巴胺能药物的情况下记录了 30 分钟的静息态活动。通过低频相位和高频伽马振幅之间的相位-振幅耦合确定 RSN，并比较不同条件（即术前与术后）之间的差异。我们确定了所有条件下的四个 RSN：感觉运动、视觉、额枕和额部。每个 RSN 都因电极植入而发生改变。重要的是，这些变化不仅局限于电极轨迹附近的空间。有趣的是，术前 RSN 在空间重叠方面与健康对照 RSN 更匹配，尽管电击效应与运动改善有关。我们的发现表明，电极植入引起的电击效应会在不同的功能 RSN 中引起大脑广泛的变化。
