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豚鼠心脏中缩醛磷脂的分布及酰基组成

The distribution and acyl composition of plasmalogens in guinea pig heart.

作者信息

Arthur G, Mock T, Zaborniak C, Choy P C

出版信息

Lipids. 1985 Oct;20(10):693-8. doi: 10.1007/BF02534389.

DOI:10.1007/BF02534389
PMID:4058266
Abstract

In guinea pig heart homogenate, 34% of both choline and ethanolamine phosphoglycerides were in the form of plasmalogens (1-alkenyl, 2-acyl glycerophospholipid). Plasmalogens accounted for 39% of the choline phosphoglycerides and 36% of the ethanolamine phosphoglycerides in the mitochondrial fraction. Ethanolamine plasmalogen was the major ethanolamine phosphoglyceride (63%) in the guinea pig heart microsomal fraction. A high arachidonyl content was found in both diacyl and 1-alkenyl, 2-acyl glycerophosphoethanolamine. The C-2 fatty acyl profiles of the diacyl and 1-alkenyl, 2-acyl choline phosphoglycerides differed considerably from each other in the homogenate as well as in the subcellular fractions. Significant differences in the C-2 fatty acyl profiles also were observed in diacyl and 1-alkenyl, 2-acyl ethanolamine phosphoglycerides. Such differences suggest there is no direct metabolic relationship between the diacyl glycerophosphocholine (-ethanolamine) and its plasmalogen analog.

摘要

在豚鼠心脏匀浆中,胆碱和乙醇胺磷酸甘油酯均有34%以缩醛磷脂(1-烯基、2-酰基甘油磷脂)的形式存在。在豚鼠心脏线粒体组分中,缩醛磷脂占胆碱磷酸甘油酯的39%,占乙醇胺磷酸甘油酯的36%。乙醇胺缩醛磷脂是豚鼠心脏微粒体组分中主要的乙醇胺磷酸甘油酯(占63%)。在二酰基甘油磷酸乙醇胺和1-烯基、2-酰基甘油磷酸乙醇胺中均发现了高含量的花生四烯酰基。在匀浆以及亚细胞组分中,二酰基和1-烯基、2-酰基胆碱磷酸甘油酯的C-2脂肪酸酰基谱彼此差异很大。在二酰基和1-烯基、2-酰基乙醇胺磷酸甘油酯中也观察到C-2脂肪酸酰基谱存在显著差异。这些差异表明二酰基甘油磷酸胆碱(-乙醇胺)与其缩醛磷脂类似物之间不存在直接的代谢关系。

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