Song Fei, Li Jinyu, Tang Fenzhen, Tang Yandong, Si Bailu
State Key Laboratory of Robotics, Shenyang Institute of Automation Chinese Academy of Sciences, Shenyang, 110016 China.
University of Chinese Academy of Sciences, Beijing, 100049 China.
Cogn Neurodyn. 2025 Dec;19(1):103. doi: 10.1007/s11571-025-10254-w. Epub 2025 Jun 26.
Animals in nature exhibit exceptional navigational abilities, primarily due to the hippocampus's capacity to form and utilize spatial and non-spatial memories. However, existing models often fail to accurately capture the dynamic interplay between different hippocampal regions. This study presents a unified navigation model inspired by the functional interactions between the hippocampus and surrounding neural circuits, with a focus on the transition mechanisms between vector-based navigation, controlled by grid cells, and hierarchical memory-based navigation, coordinated by the ventral-dorsal hippocampal axis. Simulations show that the model effectively replicates complex path-planning behaviors, such as robust direction selection and efficient shortcut finding, similar to those observed in advanced animals. Furthermore, simulations of hippocampal lesions indicate that ventral lesions increase cognitive load without disrupting planned paths, while dorsal lesions cause additional trajectory oscillations due to impaired spatial memory recall. These findings provide new insights into hippocampal navigation strategies and suggest potential applications for studying memory, learning, and cognitive function across various contexts.
The online version contains supplementary material available at 10.1007/s11571-025-10254-w.
自然界中的动物展现出卓越的导航能力，这主要归功于海马体形成和利用空间及非空间记忆的能力。然而，现有的模型往往无法准确捕捉不同海马体区域之间的动态相互作用。本研究提出了一种统一的导航模型，其灵感来源于海马体与周围神经回路之间的功能相互作用，重点关注由网格细胞控制的基于矢量的导航与由腹侧 - 背侧海马轴协调的基于层次记忆的导航之间的转换机制。模拟结果表明，该模型有效地复制了复杂的路径规划行为，如稳健的方向选择和高效的捷径寻找，类似于在高等动物中观察到的行为。此外，海马体损伤的模拟表明，腹侧损伤会增加认知负荷但不会扰乱规划路径，而背侧损伤由于空间记忆回忆受损会导致额外的轨迹振荡。这些发现为海马体导航策略提供了新的见解，并为研究各种情境下的记忆、学习和认知功能提出了潜在的应用。
在线版本包含可在10.1007/s11571 - 025 - 10254 - w获取的补充材料。
