Chakkalaparambil Dileep Navyamol, Chiu Chi-Wei, Wu Ching-Tse, Chang Chuang-Rung, Lo Chih-Yu
Institute of Biotechnology, College of Life Science and Medicine, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu City 300044, Taiwan.
School of Medicine, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu City 300044, Taiwan.
BBA Adv. 2025 Jun 11;8:100164. doi: 10.1016/j.bbadva.2025.100164. eCollection 2025.
Curcumin and its curcuminoid derivatives extracted from turmeric have been investigated for their potential therapeutic benefits in cancer treatment. Curcuminoids 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one and bisdemethoxycurcumin can be obtained from . Despite their similar chemical structures, the effects of these curcuminoids on cellular functions and their therapeutic potential require further characterization. This study examined the impact of 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one and bisdemethoxycurcumin on human cancer cell lines and mouse embryonic fibroblasts. Our findings suggest that curcuminoids induce a shift in mitochondria dynamics toward fission. Exposure to curcuminoids resulted in attenuated mitochondrial activity, decreased mitochondrial mass, reduced reactive oxygen species (ROS) levels, and decreased membrane potential, accompanied by alterations in Drp1 phosphorylation. Notably, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one had more pronounced effects than curcumin and bisdemethoxycurcumin. Curcuminoids derived from influence mitochondrial function and cell survival through Drp1 phosphorylation, indicating their potential for cancer therapy via the modulation of mitochondrial function.
姜黄素及其从姜黄中提取的姜黄素类衍生物在癌症治疗中的潜在治疗益处已得到研究。姜黄素类化合物1,7-双（4-羟基苯基）-1,4,6-庚三烯-3-酮和双去甲氧基姜黄素可从……获得。尽管它们的化学结构相似，但这些姜黄素类化合物对细胞功能的影响及其治疗潜力仍需要进一步表征。本研究考察了1,7-双（4-羟基苯基）-1,4,6-庚三烯-3-酮和双去甲氧基姜黄素对人癌细胞系和小鼠胚胎成纤维细胞的影响。我们的研究结果表明，姜黄素类化合物会使线粒体动力学向裂变方向转变。暴露于姜黄素类化合物会导致线粒体活性减弱、线粒体质量减少、活性氧（ROS）水平降低以及膜电位下降，并伴有动力相关蛋白1（Drp1）磷酸化的改变。值得注意的是，1,7-双（4-羟基苯基）-1,4,6-庚三烯-3-酮的作用比姜黄素和双去甲氧基姜黄素更为显著。源自……的姜黄素类化合物通过Drp1磷酸化影响线粒体功能和细胞存活，表明它们通过调节线粒体功能具有癌症治疗潜力。
