Pratt Tremblay Gabrielle, Han Arum, Sucha Ewa, Hsu Helen, Donelle Jessy, Corsi Daniel J
School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
J Pediatr Clin Pract. 2025 Jun 2;17:200151. doi: 10.1016/j.jpedcp.2025.200151. eCollection 2025 Sep.
Cannabis use among expectant mothers has increased steadily over the past two decades. We compared the long-term health services use of offspring prenatally exposed to cannabis to that of matched, unexposed offspring.
We conducted a retrospective cohort study using linked perinatal and health administrative databases of all live, singleton births in Ontario, Canada hospitals between April 1, 2007 and March 31, 2012. Infants were followed until March 31, 2017, with a primary outcome of primary care visits up to age 10. Secondary outcomes included rates of outpatient psychiatrist visits, emergency department visits and hospitalizations. We used adjusted Poisson regression to assess differences in rates of health service use between children with and without exposure to prenatal cannabis.
We included 508 025 infants, 3248 (0.6%) had cannabis exposure. Prenatal cannabis use was associated with a decreased rate of primary care physician visits (adjusted rate ratio [aRR]: 0.86, 95% confidence interval [CI]: 0.84-0.87) and an increase in the rate of outpatient psychiatrist visits (aRR: 1.29, 95% CI: 1.00-1.66), emergency department visits (aRR: 1.05, 95% CI: 1.03-1.08), and hospitalizations (aRR: 1.12, 95% CI: 1.04-1.20). Among preterm offspring, cannabis was associated with a decrease in primary care visits but no difference in other visits. Among those in the highest income quintiles, cannabis use was associated with a two-fold increase in the rate of outpatient psychiatrist visits.
Offspring exposed to prenatal cannabis receive fewer primary care visits but have increased rates of visiting health care specialists past the neonatal period.
在过去二十年中，孕妇使用大麻的情况呈稳步上升趋势。我们将产前暴露于大麻的后代与匹配的未暴露后代的长期医疗服务使用情况进行了比较。
我们利用加拿大安大略省医院2007年4月1日至2012年3月31日期间所有活产单胎婴儿的围产期与卫生行政数据库进行了一项回顾性队列研究。对婴儿进行随访直至2017年3月31日，主要结局是10岁前的初级保健就诊次数。次要结局包括门诊精神科就诊率、急诊科就诊率和住院率。我们使用调整后的泊松回归来评估产前暴露于大麻的儿童与未暴露儿童之间医疗服务使用率的差异。
我们纳入了508025名婴儿，其中3248名（0.6%）有大麻暴露史。产前使用大麻与初级保健医生就诊率降低相关（调整率比[aRR]：0.86，95%置信区间[CI]：0.84 - 0.87），与门诊精神科就诊率增加相关（aRR：1.29，95% CI：1.00 - 1.66）、急诊科就诊率增加相关（aRR：1.05，95% CI：1.03 - 1.08）以及住院率增加相关（aRR：1.12，95% CI：1.04 - 1.20）。在早产后代中，大麻与初级保健就诊次数减少相关，但在其他就诊方面无差异。在收入最高的五分之一人群中，使用大麻与门诊精神科就诊率增加两倍相关。
产前暴露于大麻的后代接受的初级保健就诊较少，但在新生儿期过后看专科医生的比率增加。
