School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia; Dream Science and Technology College, Dessie 1466, Amhara region, Ethiopia; Department of Public Health, College of Medicine and Health Sciences, Samara University 132, Semera, Ethiopia.
School of Population Health, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Psychiatry Res. 2024 Jul;337:115971. doi: 10.1016/j.psychres.2024.115971. Epub 2024 May 20.
This study aimed to investigate the association between pre-pregnancy, prenatal and perinatal exposures to cannabis use disorder (CUD) and the risk of autism spectrum disoder (ASD) in offspring. Data were drawn from the New South Wales (NSW) Perinatal Data Collection (PDC), population-based, linked administrative health data encompassing all-live birth cohort from January 2003 to December 2005. This study involved 222 534 mother-offspring pairs. . The exposure variable (CUD) and the outcome of interest (ASD) were identified using the 10th international disease classification criteria, Australian Modified (ICD-10-AM). We found a three-fold increased risk of ASD in the offspring of mothers with maternal CUD compared to non-exposed offspring. In our sensitivity analyses, male offspring have a higher risk of ASD associated with maternal CUD than their female counterparts. In conclusion, exposure to maternal CUD is linked to a higher risk of ASD in offspring, with a stronger risk in male offspring. Further research is needed to understand these gender-specific effects and the relationship between maternal CUD and ASD risk in children.
本研究旨在探讨母亲在孕前、孕期和围产期接触大麻使用障碍（CUD）与后代自闭症谱系障碍（ASD）风险之间的关联。数据来自新南威尔士州（NSW）围产期数据收集（PDC），这是一项基于人群的、链接的行政健康数据，涵盖了 2003 年 1 月至 2005 年 12 月期间的所有活产队列。本研究涉及 222534 对母婴。使用第 10 次国际疾病分类标准（ICD-10-AM）确定暴露变量（CUD）和感兴趣的结局（ASD）。与未暴露的后代相比，患有母体 CUD 的母亲的后代患 ASD 的风险增加了三倍。在敏感性分析中，与母体 CUD 相关的 ASD 风险在男性后代中高于女性后代。总之，母亲 CUD 的暴露与后代 ASD 风险增加有关，男性后代的风险更高。需要进一步研究以了解这些性别特异性效应以及母体 CUD 与儿童 ASD 风险之间的关系。
