Cervera-Hernandez Miguel E, Jariwala Sunit P
Infectious Diseases, Sanford University of South Dakota Medical Center, Sioux Falls, 57105, South Dakota, USA.
Division of Allergy/Immunology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, 10467, USA.
Med Mycol Case Rep. 2025 Jun 7;49:100711. doi: 10.1016/j.mmcr.2025.100711. eCollection 2025 Sep.
Chronic cavitary pulmonary histoplasmosis requires prolonged treatment with itraconazole. However, hypersensitivity reactions to itraconazole, though rare, pose a challenge due to limited data on the efficacy and cross-reactivity of the newer azoles. We present a case of chronic cavitary pulmonary histoplasmosis successfully treated with isavuconazole following an itraconazole-induced hypersensitivity reaction, highlighting its potential as an alternative therapy in such cases.
慢性空洞型肺组织胞浆菌病需要用伊曲康唑进行长期治疗。然而，对伊曲康唑的过敏反应虽然罕见，但由于关于新型唑类药物的疗效和交叉反应的数据有限，这构成了一项挑战。我们报告了1例慢性空洞型肺组织胞浆菌病患者，在发生伊曲康唑诱导的过敏反应后，成功地用艾沙康唑进行了治疗，突出了其在此类病例中作为替代疗法的潜力。
