伊曲康唑发生超敏反应后采用艾沙康唑治疗慢性空洞型肺组织胞浆菌病。
Chronic cavitary pulmonary histoplasmosis treated with isavuconazole after a hypersensitivity reaction to itraconazole.
作者信息
Cervera-Hernandez Miguel E, Jariwala Sunit P
机构信息
Infectious Diseases, Sanford University of South Dakota Medical Center, Sioux Falls, 57105, South Dakota, USA.
Division of Allergy/Immunology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, 10467, USA.
出版信息
Med Mycol Case Rep. 2025 Jun 7;49:100711. doi: 10.1016/j.mmcr.2025.100711. eCollection 2025 Sep.
Chronic cavitary pulmonary histoplasmosis requires prolonged treatment with itraconazole. However, hypersensitivity reactions to itraconazole, though rare, pose a challenge due to limited data on the efficacy and cross-reactivity of the newer azoles. We present a case of chronic cavitary pulmonary histoplasmosis successfully treated with isavuconazole following an itraconazole-induced hypersensitivity reaction, highlighting its potential as an alternative therapy in such cases.
慢性空洞型肺组织胞浆菌病需要用伊曲康唑进行长期治疗。然而，对伊曲康唑的过敏反应虽然罕见，但由于关于新型唑类药物的疗效和交叉反应的数据有限，这构成了一项挑战。我们报告了1例慢性空洞型肺组织胞浆菌病患者，在发生伊曲康唑诱导的过敏反应后，成功地用艾沙康唑进行了治疗，突出了其在此类病例中作为替代疗法的潜力。
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