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卫星细胞对局部骨骼肌损伤的反应。

Response of satellite cells to focal skeletal muscle injury.

作者信息

Schultz E, Jaryszak D L, Valliere C R

出版信息

Muscle Nerve. 1985 Mar-Apr;8(3):217-22. doi: 10.1002/mus.880080307.

Abstract

The time course and pattern of the initiation of satellite cell mitoses was studied following a crush injury of the distal third of the 30-day-old rat extensor digitorum longus, a muscle in which myofibers run the entire length of the belly. Satellite cell mitotic activity was monitored using autoradiography after injection of 3H-thymidine. Satellite cell labeling rose above control values by 15 hours post injury at the injured site and by 20 hours in the middle third or adjacent undamaged portion of the muscle. Labeling decreased in the proximal third of the muscle, so that by 25 hours post injury, a gradient of labeling was established along the muscle length. Electron microscopy (EM) quantitation showed that the reduced labeling in the proximal third resulted from a reduction in satellite cell numbers. The results suggest that mitotic activity of satellite cells after localized injury occurs mainly at or near the site of injury, but that many of the dividing cells have migrated from undamaged areas distant from the lesion site.

摘要

在对30日龄大鼠趾长伸肌(一种肌纤维贯穿肌腹全长的肌肉)远侧三分之一处进行挤压损伤后,研究了卫星细胞有丝分裂起始的时间进程和模式。在注射3H-胸腺嘧啶核苷后,利用放射自显影术监测卫星细胞的有丝分裂活性。在损伤后15小时,损伤部位的卫星细胞标记率高于对照值,而在肌肉的中间三分之一或相邻未受损部分,标记率在损伤后20小时高于对照值。肌肉近侧三分之一处的标记率下降,因此在损伤后25小时,沿肌肉长度建立了一个标记梯度。电子显微镜(EM)定量分析表明,近侧三分之一处标记率降低是由于卫星细胞数量减少所致。结果表明,局部损伤后卫星细胞的有丝分裂活性主要发生在损伤部位或其附近,但许多分裂细胞是从远离损伤部位的未受损区域迁移而来的。

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