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老年腹部手术患者教育水平与术后谵妄之间的关联:一项两样本队列研究

Association between educational level and postoperative delirium in older patients undergoing abdominal surgery: a two-sample cohort study.

作者信息

Xiang Mingju, Liu Jie, Wang Jing, Li Feng, Fan Tingting, Tang Jia

机构信息

Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Front Med (Lausanne). 2025 Jun 13;12:1581503. doi: 10.3389/fmed.2025.1581503. eCollection 2025.


DOI:10.3389/fmed.2025.1581503
PMID:40584703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12202355/
Abstract

BACKGROUND: Postoperative delirium (POD) is a critical complication in older patients following abdominal surgery, significantly contributing to delayed recovery and prolonged hospital stays. Understanding the risk factors associated with POD is essential for developing effective prevention and intervention strategies. This study investigates the potential impact of educational attainment on the incidence of delirium in this patient population. METHODS: This study utilized a two-sample cohort design to collect demographic and educational attainment, and clinical data, including, from older patients undergoing abdominal surgery. The assessment of delirium during the recovery phase was conducted using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and the 3-Minute Diagnostic Interview for Confusion Assessment Method within the first three postoperative days. In the exploratory cohort, the relationship between education and postoperative delirium was determined by univariate analysis, followed by multivariate logistic regression to determine that education was an independent predictor. The identified risk factors were subsequently validated in an independent validation cohort to ensure robustness and generalizability. RESULTS: The exploratory cohort consisted of 342 cases, while the validation cohort included 150 cases. Exploratory cohort regression analysis identified lower educational attainment and procedures or anesthesia lasting longer than 4 h as independent risk factors for POD. Anesthesia time of more than 4 h was also an independent risk factor for delirium during resuscitation. CONCLUSION: Lower educational attainment is significantly related to an increased chance of POD in older adults undergoing abdominal procedures. These findings suggest that preoperative assessments should incorporate educational level as a potential risk factor, providing a basis for targeted prevention and intervention strategies to mitigate POD.

摘要

背景:术后谵妄(POD)是老年患者腹部手术后的一种严重并发症,显著导致恢复延迟和住院时间延长。了解与POD相关的风险因素对于制定有效的预防和干预策略至关重要。本研究调查了教育程度对该患者群体谵妄发生率的潜在影响。 方法:本研究采用两样本队列设计,收集了接受腹部手术的老年患者的人口统计学和教育程度以及临床数据。在术后前三天内,使用重症监护病房意识模糊评估方法(CAM-ICU)和意识模糊评估方法的3分钟诊断访谈对恢复阶段的谵妄进行评估。在探索性队列中,通过单因素分析确定教育与术后谵妄之间的关系,随后进行多因素逻辑回归以确定教育是一个独立预测因素。随后在独立验证队列中对确定的风险因素进行验证,以确保其稳健性和普遍性。 结果:探索性队列包括342例病例,而验证队列包括150例病例。探索性队列回归分析确定教育程度较低以及手术或麻醉持续时间超过4小时是POD的独立风险因素。复苏期间麻醉时间超过4小时也是谵妄的独立风险因素。 结论:教育程度较低与接受腹部手术的老年人发生POD的几率增加显著相关。这些发现表明,术前评估应将教育水平作为潜在风险因素纳入,为减轻POD的针对性预防和干预策略提供依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/12202355/6e1e4f1952de/fmed-12-1581503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/12202355/d4fea0274c8f/fmed-12-1581503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/12202355/e0acc3f8907a/fmed-12-1581503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/12202355/6e1e4f1952de/fmed-12-1581503-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/12202355/d4fea0274c8f/fmed-12-1581503-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/12202355/e0acc3f8907a/fmed-12-1581503-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/12202355/6e1e4f1952de/fmed-12-1581503-g003.jpg

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本文引用的文献

[1]
Sodium Butyrate Ameliorates Postoperative Delirium by Regulating Gut Microbiota Dysbiosis to Inhibit Astrocyte Activation in Aged Mice.

Neurochem Res. 2024-12

[2]
Incidence of post-operative delirium increases as severity of frailty increases.

Age Ageing. 2024-8-6

[3]
Anesthesia/surgery activate MMP9 leading to blood-brain barrier disruption, triggering neuroinflammation and POD-like behavior in aged mice.

Int Immunopharmacol. 2024-6-30

[4]
Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study.

Perioper Med (Lond). 2024-5-16

[5]
Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers - in cognitively unimpaired older adults.

Brain Behav Immun. 2023-10

[6]
Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation.

Cells. 2022-9-21

[7]
Association of cholinesterase activities and POD in older adult abdominal surgical patients.

BMC Anesthesiol. 2022-9-16

[8]
The Age-adjusted Charlson Comorbidity Index predicts post-operative delirium in the elderly following thoracic and abdominal surgery: A prospective observational cohort study.

Front Aging Neurosci. 2022-8-17

[9]
Risk factors and effect of postoperative delirium on adverse surgical outcomes in older adults after elective abdominal cancer surgery in Taiwan.

Asian J Surg. 2023-3

[10]
Post-Operative Cognitive Impairment: A Cognitive Epidemiology Perspective.

J Intell. 2022-3-11

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