Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, 0373 Oslo, Norway.
Department of Geriatric Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Campus Ahus, Oslo, Norway.
Brain Behav Immun. 2023 Oct;113:56-65. doi: 10.1016/j.bbi.2023.06.027. Epub 2023 Jul 1.
Concentrations of pro-inflammatory cytokines -interleukin-6 (IL-6) and interleukin-8 (IL-8) - are increased with age and in Alzheimer's disease (AD). It is not clear whether concentrations of IL-6 and IL-8 in the central nervous system predict later brain and cognitive changes over time nor whether this relationship is mediated by core AD biomarkers. Here, 219 cognitively healthy older adults (62-91 years), with baseline cerebrospinal fluid (CSF) measures of IL-6 and IL-8 were followed over time - up to 9 years - with assessments that included cognitive function, structural magnetic resonance imaging, and CSF measurements of phosphorylated tau (p-tau) and amyloid-β (Aβ-42) concentrations (for a subsample). Higher baseline CSF IL-8 was associated with better memory performance over time in the context of lower levels of CSF p-tau and p-tau/Aβ-42 ratio. Higher CSF IL-6 was related to less CSF p-tau changes over time. The results are in line with the hypothesis suggesting that an up-regulation of IL-6 and IL-8 in the brain may play a neuroprotective role in cognitively healthy older adults with lower load of AD pathology.
促炎细胞因子 - 白细胞介素-6（IL-6）和白细胞介素-8（IL-8）的浓度随着年龄的增长和阿尔茨海默病（AD）而增加。目前尚不清楚中枢神经系统中 IL-6 和 IL-8 的浓度是否可以预测随着时间的推移大脑和认知的后续变化，也不清楚这种关系是否通过 AD 的核心生物标志物来介导。在这里，219 名认知健康的老年人（62-91 岁），在基线时测量了脑脊液（CSF）中的 IL-6 和 IL-8，随后进行了长达 9 年的随访 - 包括认知功能、结构磁共振成像和 CSF 测量磷酸化 tau（p-tau）和淀粉样蛋白-β（Aβ-42）浓度（对于亚样本）。在较低的 CSF p-tau 和 p-tau/Aβ-42 比值水平下，较高的基线 CSF IL-8 与记忆表现随时间的改善有关。较高的 CSF IL-6 与随时间推移 CSF p-tau 的变化较少有关。结果与假设一致，即大脑中 IL-6 和 IL-8 的上调可能在 AD 病理负荷较低的认知健康老年人中发挥神经保护作用。
