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对有色人种皮肤脱发性毛囊炎的流行病学、临床及治疗见解:一项17例病例的回顾性描述性研究

Epidemiological, Clinical, and Therapeutic Insights into Folliculitis Decalvans in Skin of Color: A Retrospective Descriptive Study of 17 Cases.

作者信息

Loubaris Zineb, Taib Hajar Elhassani, Benzekri Laila, Meziane Mariame

机构信息

Department of Dermatology, Ibn Sina University Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University of Rabat, Rabat, Morocco.

出版信息

Skin Appendage Disord. 2025 May 28:1-6. doi: 10.1159/000546565.

Abstract

INTRODUCTION

Folliculitis decalvans (FD) is a neutrophilic scarring alopecia characterized by follicular pustules, crusts, and tufted hair. Its etiology remains unclear, though infection and immune dysfunction are implicated. This study investigates the clinical, dermoscopic, and therapeutic aspects of FD in a skin of color population. The objective of our study was to analyze the epidemiological profile, clinical diversity, diagnostic features, and treatment strategies for FD patients.

METHODS

A retrospective, descriptive study of 17 FD patients was conducted at Ibn Sina University Hospital, Rabat, over 4 years. Diagnosis was based on clinical, dermoscopic, and histological findings. Data collected included demographics, disease onset, comorbidities, symptoms, severity grading, and therapeutic responses.

RESULTS

The cohort comprised 17 patients (8 men, 9 women) with a median age of 37.2 years. Phototype IV was predominant (47.1%). The vertex was the most affected site (82.4%). Scarring alopecia was present in all cases, with perifollicular erythema (100%) and tufted hair (88.2%) being the most common dermoscopic findings. Grade 3 severity was observed in 55.5% of female patients. Topical and oral antibiotics, including doxycycline, were the most prescribed treatments. Resistance to treatment was more common in women.

CONCLUSIONS

FD in skin of color patients exhibits clinical, dermoscopic, and therapeutic patterns comparable to global data, though higher severity and pustule prevalence were noted. Doxycycline and topical agents remain key therapeutic options. Larger studies are needed to elucidate pathogenesis and optimize management strategies.

摘要

引言

脱发性毛囊炎(FD)是一种嗜中性瘢痕性秃发,其特征为毛囊脓疱、结痂和簇状发。尽管感染和免疫功能障碍与之相关,但其病因仍不清楚。本研究调查了有色人种皮肤中FD的临床、皮肤镜检查和治疗方面。我们研究的目的是分析FD患者的流行病学特征、临床多样性、诊断特征和治疗策略。

方法

在拉巴特的伊本·西那大学医院对17例FD患者进行了为期4年的回顾性描述性研究。诊断基于临床、皮肤镜检查和组织学结果。收集的数据包括人口统计学、疾病发作、合并症、症状、严重程度分级和治疗反应。

结果

该队列包括17例患者(8名男性,9名女性),中位年龄为37.2岁。IV型皮肤类型占主导(47.1%)。头顶是受影响最严重的部位(82.4%)。所有病例均存在瘢痕性秃发,毛囊周围红斑(100%)和簇状发(88.2%)是最常见的皮肤镜检查结果。55.5%的女性患者观察到3级严重程度。局部和口服抗生素,包括强力霉素,是最常用的治疗方法。女性对治疗的耐药性更常见。

结论

有色人种皮肤患者的FD在临床、皮肤镜检查和治疗模式上与全球数据相当,但注意到严重程度和脓疱患病率更高。强力霉素和局部用药仍然是关键的治疗选择。需要进行更大规模的研究来阐明发病机制并优化管理策略。

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本文引用的文献

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Folliculitis decalvans in women: A retrospective multicentre study of 150 patients.
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Folliculitis Decalvans and Lichen Planopilaris Phenotypic Spectrum: A Case Report.脱发性毛囊炎和平顶毛发苔藓表型谱:病例报告
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Folliculitis decalvans.脱发性毛囊炎
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