Powell J J, Dawber R P, Gatter K
Departments of Dermatology and Cellular Science, The Oxford Radcliffe Hospital, Oxford OX3 7LJ, U.K.
Br J Dermatol. 1999 Feb;140(2):328-33. doi: 10.1046/j.1365-2133.1999.02675.x.
In a series of 18 patients with folliculitis decalvans attending the Oxford hair clinic, eight were found to have areas of tufted folliculitis either at presentation or follow-up. There was no difference between these two groups in their presentation, clinical course, growth of causative organism (Staphylococcus aureus) or investigations including histology. We suggest that these two entities form part of a spectrum of a single disease. We performed lymphocyte staining on affected scalp biopsies, including CD4: CD8 and T-cell/B-cell ratios, but found no evidence of local immune suppression or failure which would explain the abnormal host response to a common pathogen in this rare condition. We introduced a new treatment regimen for these patients, oral rifampicin and oral clindamycin together for 10 weeks. Ten of the 18 patients have responded well with no evidence of recurrence 2-22 months after one course of treatment, and 15 of the 18 responded after two or three courses.
在牛津毛发诊所就诊的18例脱发性毛囊炎患者中，有8例在初诊或随访时被发现患有簇状毛囊炎。这两组患者在临床表现、临床病程、致病微生物（金黄色葡萄球菌）生长情况或包括组织学在内的各项检查方面均无差异。我们认为这两种病症是单一疾病谱系的一部分。我们对受影响的头皮活检组织进行了淋巴细胞染色，包括CD4:CD8和T细胞/B细胞比率，但未发现局部免疫抑制或功能障碍的证据，而这种免疫抑制或功能障碍本可解释在这种罕见病症中宿主对常见病原体的异常反应。我们为这些患者引入了一种新的治疗方案，口服利福平与口服克林霉素联合使用10周。18例患者中有10例反应良好，在一个疗程治疗后的2至22个月内无复发迹象，18例中有15例在两个或三个疗程后有反应。
