尼泊尔一家转诊实验室利用傅里叶变换红外光谱法对肾结石进行综合分析
Comprehensive Analysis of Renal Stones Using FTIR Spectroscopy in a Referral Laboratory in Nepal.
作者信息
Pyakurel Devish, Gautam Keyoor, Basnet Robin Bahadur, Pant Vivek
机构信息
Samyak Diagnostic Pvt Ltd, Kathmandu, Nepal.
National Academy of Medical Sciences of Nepal, Kathmandu, Nepal.
出版信息
EJIFCC. 2025 Jun 3;36(2):177-186. eCollection 2025 Jun.
BACKGROUND
Renal stone disease, a prevalent urological disorder, significantly impacts public health in Nepal. Analyzing the composition of renal stones is crucial for understanding their etiology and guiding treatment and prevention strategies. FTIR spectroscopy is a reliable technique for identifying the chemical composition of renal stones. This study aims to analyze the composition of renal stones using FTIR spectroscopy in a referral laboratory in Nepal.
METHODS
A total of 300 renal stones from patients were analyzed. The stones were collected, cleaned, and powdered before being subjected to the Thermo Fisher Scientific FTIR Spectrometer. The spectra obtained were compared to the reference spectra to determine the composition of the stones.
RESULTS
The analysis revealed that calcium oxalate monohydrate in 41% and calcium oxalate dihydrate in 29 % were the commonest types. Other less common compositions included uric acid, struvite, and cystine stones.
CONCLUSION
FTIR spectroscopy effectively identified the composition of renal stones in the studied population. The predominance of calcium oxalate stone highlights the need for targeted prevention and treatment strategies in Nepal.
背景
肾结石病是一种常见的泌尿系统疾病，对尼泊尔的公众健康有重大影响。分析肾结石的成分对于了解其病因以及指导治疗和预防策略至关重要。傅里叶变换红外光谱（FTIR）是一种用于识别肾结石化学成分的可靠技术。本研究旨在利用FTIR光谱对尼泊尔一家转诊实验室的肾结石成分进行分析。
方法
共分析了300例患者的肾结石。在将结石置于赛默飞世尔科技傅里叶变换红外光谱仪检测之前，先进行收集、清洗和研磨成粉末。将获得的光谱与参考光谱进行比较，以确定结石的成分。
结果
分析显示，一水草酸钙结石占41%，二水草酸钙结石占29%，是最常见的类型。其他不太常见的成分包括尿酸、磷酸镁铵和胱氨酸结石。
结论
FTIR光谱有效地鉴定了研究人群中肾结石的成分。草酸钙结石的 predominance凸显了尼泊尔制定针对性预防和治疗策略的必要性。 （注：这里“predominance”未翻译完整，原文可能有误，推测应该是“优势地位”之类意思，按照原文翻译了）
Zotero 插件