Yan Xiaojie, Zheng Wenfu, Yu Yiming, Liu Rufang, Gong Youhuan, Huang Mengting, Fan Mingde, Wang Le
Academician Workstation, Cancer Research Center, The Jiangxi Province Key Laboratory for Diagnosis, Treatment, and Rehabilitation of Cancer in Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang, 330004, Jiangxi, PR China.
CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Haidian District, Beijing, 100190, PR China.
Mater Today Bio. 2025 Jun 10;33:101977. doi: 10.1016/j.mtbio.2025.101977. eCollection 2025 Aug.
Diabetic wounds, characterized by recurrent infections, drug resistance, and immunosuppression, pose a formidable clinical challenge which can hardly be adequately managed by conventional antibiotics. Herein, we present dextran-functionalized cerium oxide nanoparticles (Dex-CeNPs) to cure bacterial infected diabetic wounds. The Dex-CeNPs not only had excellent antibacterial activity, but also promoted the shift of macrophages from the proinflammatory M1 phenotype to the proregenerative M2 phenotype. By synergizing the antibacterial activity and immune modulating activity, the Dex-CeNPs promoted the healing of methicillin-resistant (MRSA)-infected diabetic wound and prevented infection recurrence in mice. Our study provides a strategy for treating intractable diabetic wounds.
糖尿病伤口具有反复感染、耐药性和免疫抑制等特征，给临床带来了巨大挑战，传统抗生素难以对其进行有效治疗。在此，我们展示了葡聚糖功能化的氧化铈纳米颗粒（Dex-CeNPs）可治愈细菌感染的糖尿病伤口。Dex-CeNPs不仅具有出色的抗菌活性，还能促进巨噬细胞从促炎的M1表型向促再生的M2表型转变。通过协同抗菌活性和免疫调节活性，Dex-CeNPs促进了耐甲氧西林金黄色葡萄球菌（MRSA）感染的糖尿病伤口愈合，并防止了小鼠感染复发。我们的研究为治疗难治性糖尿病伤口提供了一种策略。
