Greenman Michelle, McNamara Blair, Ettorre Victoria, Buza Natalia, Azodi Masoud
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT, USA.
Department of Pathology, Yale University, School of Medicine, New Haven, CT, USA.
Gynecol Oncol Rep. 2025 Jun 9;59:101778. doi: 10.1016/j.gore.2025.101778. eCollection 2025 Jun.
Treatment of a uterine extragonadal yolk sac tumor (EGYST) typically requires hysterectomy. Fertility preserving strategies are essential for young women who have not yet met their reproductive goals. Here we explore an option for uterine preservation.
A 30-year-old presented with what was thought to be a degenerating fibroid but ultimately was diagnosed as an extragonadal yolk sac tumor. The myometrium and endometrium adjacent to the tumor were resected with negative margins, the uterus was reconstructed, and a fertility preserving staging procedure was performed followed by chemotherapy with bleomycin, etoposide, and cisplatin. She had a single recurrence which was surgically managed.
The patient has had no evidence of disease for the past six years since the recurrence was diagnosed. The patient has since spontaneously conceived pregnancy.
This case successfully presents a surgical approach to managing a uterine extragonadal yolk sac tumor in a young woman that desired future fertility. A uterine wedge resection and reconstruction was able to adequately resect the tumor. This represents a treatment option for uterine preservation in women that have not yet completed childbearing.
子宫外胚层卵黄囊瘤（EGYST）的治疗通常需要子宫切除术。对于尚未实现生育目标的年轻女性而言，保留生育能力的策略至关重要。在此，我们探讨一种保留子宫的方案。
一名30岁女性最初被认为患有变性肌瘤，但最终被诊断为性腺外卵黄囊瘤。切除肿瘤周围的子宫肌层和子宫内膜，切缘阴性，重建子宫，并进行保留生育功能的分期手术，随后使用博来霉素、依托泊苷和顺铂进行化疗。她出现了一次复发，通过手术进行了处理。
自复发被诊断以来，该患者在过去六年中没有疾病迹象。此后，患者自然受孕。
该病例成功展示了一种针对有生育意愿的年轻女性子宫外胚层卵黄囊瘤的手术治疗方法。子宫楔形切除术和重建能够充分切除肿瘤。这为尚未完成生育的女性提供了一种保留子宫的治疗选择。
