Askarpour Moein, Jahromi Bahia Namavar, Eskandari Mohammad Hadi, Maghsoudi Zahra, Famouri Mandana, Bedeltavana Alireza, Hejazi Najmeh
Department of Clinical Nutrition, School of Nutrition and Food Sciences Shiraz University of Medical Sciences Shiraz Iran.
Students' Research Committee, School of Nutrition and Food Science Shiraz University of Medical Sciences Shiraz Iran.
Food Sci Nutr. 2025 Jun 27;13(7):e70506. doi: 10.1002/fsn3.70506. eCollection 2025 Jul.
This study aimed to determine the effects of daily consumption of fortified yogurt on the metabolic health parameters in women with PCOS. In this randomized double-blind controlled trial, participants received either yogurt fortified with 10 CFU/g probiotics, 1000 IU vitamin D, and 50 IU vitamin E in the intervention group ( = 45) or plain yogurt in the control group ( = 45) for 8 weeks. The group that consumed fortified yogurt demonstrated a significant reduction in homeostatic model assessment for insulin resistance (HOMA-IR) ( = 0.040), high-sensitivity C-reactive protein (Hs-CRP) ( = 0.012), malondialdehyde ( = 0.020), and total testosterone ( = 0.042), along with an increase in serum levels of 25(OH) D ( = 0.003) and alpha-tocopherol ( = 0.020) compared to the control group. Nevertheless, further research is required to confirm the efficacy of this functional food as an adjunctive therapy for addressing metabolic health issues in PCOS patients. The Iranian Registry of Clinical Trials (IRCT20231210060323N1).
本研究旨在确定每日食用强化酸奶对多囊卵巢综合征（PCOS）女性代谢健康参数的影响。在这项随机双盲对照试验中，干预组（n = 45）的参与者食用添加了10 CFU/g益生菌、1000 IU维生素D和50 IU维生素E的酸奶，对照组（n = 45）的参与者食用普通酸奶，为期8周。与对照组相比，食用强化酸奶的组在胰岛素抵抗的稳态模型评估（HOMA-IR）（P = 0.040）、高敏C反应蛋白（Hs-CRP）（P = 0.012）、丙二醛（P = 0.020）和总睾酮（P = 0.042）方面显著降低，同时血清25(OH)D水平（P = 0.003）和α-生育酚水平（P = 0.020）有所升高。然而，需要进一步研究来证实这种功能性食品作为辅助疗法解决PCOS患者代谢健康问题的疗效。伊朗临床试验注册中心（IRCT20231210060323N1）。
