Chatzimichail Eleftherios, Chondrozoumakis Georgios, Doroodgar Farideh, Vounotrypidis Efstathios, Panos Georgios D, Feltgen Nicolas, Gatzioufas Zisis
Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland.
Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece.
Ther Adv Ophthalmol. 2025 Jun 28;17:25158414251350071. doi: 10.1177/25158414251350071. eCollection 2025 Jan-Dec.
Corneal crosslinking (CXL) was first introduced in clinical practice in 2003. Since then, this procedure has been established as the first-line treatment in the management of progressive keratoconus. Over the last years, many different protocols have emerged, each one of them with variable clinical outcomes and safety profile. Progression of keratoconus after primary CXL is very rare, but it has been reported in the literature. This review summarises the existing data on repeated CXL after primary failure, emphasising on clinical efficacy and safety.
角膜交联术（CXL）于2003年首次引入临床实践。从那时起，该手术已成为进行性圆锥角膜治疗的一线疗法。在过去几年中，出现了许多不同的方案，每个方案都有不同的临床结果和安全性。初次角膜交联术后圆锥角膜进展非常罕见，但文献中已有报道。本综述总结了初次治疗失败后重复角膜交联术的现有数据，重点关注临床疗效和安全性。
