Wach Michael M, Dineen Sean P
Department of Gastrointestinal Surgical Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Ann Surg Oncol. 2025 Jun 30. doi: 10.1245/s10434-025-17650-w.
Colorectal peritoneal metastases (CRPM) represent a significant treatment challenge for patients with colorectal cancer that significantly impact quality of life and limit survival.
Systemic chemotherapy represents the current mainstay of management for metastatic disease, but the use of cytoreductive surgery with and without hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is being established as a promising option with survival benefit for select patients.
Identifying best management practices for patients with CRPM is critical as intervention with CRS/HIPEC can carry significant risks of morbidity and mortality.
This guideline report aims to summarize the existing literature regarding optimal management of patients with CRPM and current areas of ongoing investigation.
结直肠腹膜转移(CRPM)对结直肠癌患者而言是一项重大的治疗挑战,严重影响生活质量并限制生存期。
全身化疗是目前转移性疾病治疗的主要手段,但对于部分患者,采用减瘤手术联合或不联合热灌注腹腔化疗(CRS/HIPEC)正成为一种有前景的选择,可带来生存获益。
确定CRPM患者的最佳管理方案至关重要,因为CRS/HIPEC干预可能带来显著的发病和死亡风险。
本指南报告旨在总结关于CRPM患者最佳管理的现有文献以及当前正在进行研究的领域。