Earl H M, Earl C J, Kendall B E
Neuroradiology. 1985;27(5):446-8. doi: 10.1007/BF00327613.
Temporary but considerable increase in spasticity following myelography using metrizamide at 300 mgs I/ml concentration occurred in 4 patients. In 3 of the patients the diagnosis is uncertain, but it is likely to be some form of degenerative disease involving motor pathways in two of them; the fourth case has cervical spondylotic myelopathy. The spasticity might be related to the anticholinesterase activity of metrizamide or to competitive inhibition of endogenous glucose metabolism by the deoxyglucose component of the metrizamide molecule.
4例患者在使用浓度为300毫克碘/毫升的甲泛葡胺进行脊髓造影后，出现了短暂但明显的痉挛增加。其中3例患者的诊断尚不明确，但其中2例可能患有某种涉及运动通路的退行性疾病；第4例患有颈椎病性脊髓病。痉挛可能与甲泛葡胺的抗胆碱酯酶活性有关，或者与甲泛葡胺分子中的脱氧葡萄糖成分对内源性葡萄糖代谢的竞争性抑制有关。
