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地塞米松治疗脑肿瘤患者：对局部脑血流量、血容量和氧利用的影响。

Dexamethasone treatment of brain tumor patients: effects on regional cerebral blood flow, blood volume, and oxygen utilization.

作者信息

Leenders K L, Beaney R P, Brooks D J, Lammertsma A A, Heather J D, McKenzie C G

出版信息

Neurology. 1985 Nov;35(11):1610-6. doi: 10.1212/wnl.35.11.1610.

DOI:10.1212/wnl.35.11.1610
PMID:4058751
Abstract

Regional values for cerebral blood flow, blood volume, oxygen extraction fraction, and oxygen utilization were measured, using PET, in 10 brain tumor patients before and after treatment with dexamethasone. Dexamethasone treatment decreased cerebral blood flow and blood volume and increased the fractional extraction of oxygen throughout the brain without affecting oxygen utilization. Dexamethasone probably causes direct vasoconstriction of cerebral blood vessels.

摘要

利用正电子发射断层扫描（PET）测量了10名脑肿瘤患者在接受地塞米松治疗前后大脑血流、血容量、氧摄取分数和氧利用率的区域值。地塞米松治疗降低了大脑血流和血容量，并增加了全脑的氧摄取分数，而不影响氧利用率。地塞米松可能直接导致脑血管收缩。

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