Bai Suning, Wu Qi, Song Liyun
Department of Gynecology, Hebei General Hospital, Shijiazhuang, China.
Medicine (Baltimore). 2025 Jun 27;104(26):e42945. doi: 10.1097/MD.0000000000042945.
In recent years, with the improvement of people's living standards, the incidence rate of endometrial cancer shows a rising and younger trend in the world. Early stage endometrial cancer patients have a good prognosis after surgical treatment, but late stage patients have a poor prognosis. Therefore, if biological indicators related to the occurrence and development of endometrial cancer with high sensitivity and specificity can be found, it will provide clinical reference for predicting the prognosis of endometrial cancer and evaluating treatment effectiveness. Vascular endothelial growth factor (VEGF) is a positive regulator of angiogenesis, while microvascular density (MVD) is a quantitative indicator of angiogenesis. This study investigates the expression of VEGF and MVD in endometrial cancer and normal endometrial tissue, and explores their roles in the formation and development of endometrial cancer.
Immunohistochemical technique (SP method) was used to detect the expression of VEGF and MVD in paraffin sections of 38 cases of endometrial cancer and 20 cases of normal endometrium. Statistical analysis was conducted using statistical software SPSS 17.0.
The positivity of VEGF in the endometrial cancer group was significantly higher than that in the normal endometrial group. The expression level of MVD in the endometrial cancer group was significantly higher than that in the normal endometrial group. In endometrial cancer, the expression of VEGF is positively correlated with MVD (R = 0.811, P < .001).
The expression levels of VEGF and MVD are significantly increased in endometrial cancer, and both are positively correlated in endometrial cancer. MVD is related to the surgical pathological staging, lymph node metastasis, and depth of muscle wall infiltration of endometrial cancer, indicating that local neovascularization and rich blood supply play an important role in the occurrence and development of endometrial cancer. VEGF is related to the depth of muscle wall infiltration in endometrial cancer, but not to surgical pathological staging and lymph node metastasis. It is considered that other angiogenic factors besides VEGF play a role in regulating angiogenesis during surgical pathological staging and lymph node metastasis of endometrial cancer.
近年来，随着人们生活水平的提高，子宫内膜癌的发病率在全球呈上升趋势且趋于年轻化。早期子宫内膜癌患者手术治疗后预后良好，但晚期患者预后较差。因此，若能找到与子宫内膜癌发生发展相关的高敏感性和特异性的生物学指标，将为预测子宫内膜癌的预后及评估治疗效果提供临床参考。血管内皮生长因子（VEGF）是血管生成的正调节因子，而微血管密度（MVD）是血管生成的定量指标。本研究旨在探讨VEGF和MVD在子宫内膜癌及正常子宫内膜组织中的表达情况，并探究它们在子宫内膜癌形成和发展中的作用。
采用免疫组织化学技术（SP法）检测38例子宫内膜癌石蜡切片及20例正常子宫内膜中VEGF和MVD的表达。使用统计软件SPSS 17.0进行统计分析。
子宫内膜癌组VEGF阳性率显著高于正常子宫内膜组。子宫内膜癌组MVD表达水平显著高于正常子宫内膜组。在子宫内膜癌中，VEGF的表达与MVD呈正相关（R = 0.811，P <.001）。
子宫内膜癌中VEGF和MVD的表达水平显著升高，且两者在子宫内膜癌中呈正相关。MVD与子宫内膜癌的手术病理分期、淋巴结转移及肌层浸润深度有关，表明局部新生血管形成和丰富的血供在子宫内膜癌的发生发展中起重要作用。VEGF与子宫内膜癌的肌层浸润深度有关，但与手术病理分期及淋巴结转移无关。认为在子宫内膜癌手术病理分期和淋巴结转移过程中，除VEGF外其他血管生成因子在调节血管生成中发挥作用。
