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尼泊尔三级医疗中心原发性高血压患者微量白蛋白尿的患病率及其临床关联:一项横断面研究。

Prevalence and clinical correlates of microalbuminuria among patients of essential hypertension in tertiary care center of Nepal: A cross-sectional study.

作者信息

Lamsal Lekhnath, Joshi Rinku, Bhattarai Madhur, Parajuli Bibek, Timilsina Sunil, Kunwor Bishal, Chhetri Suchit, Bhandari Sujata, Chaurel Ashish, Bhattarai Himal Bikram

机构信息

Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.

Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.

出版信息

Medicine (Baltimore). 2025 Jun 27;104(26):e43075. doi: 10.1097/MD.0000000000043075.

Abstract

Microalbuminuria is an early marker indicating renal damage and is known to predict cardiovascular morbidity and mortality in individuals with essential hypertension. However, research on the prevalence of microalbuminuria among hypertensive patients attending tertiary care centers is limited. This study aims to determine the prevalence of microalbuminuria among patients with essential hypertension in a tertiary care center and to evaluate its association with demographic and clinical parameters. A cross-sectional research study was conducted at a tertiary care facility, involving 362 patients diagnosed with essential hypertension. The study utilized a spot urine sample to assess microalbuminuria, measured by the albumin-to-creatinine ratio. Data encompassing patient demographics, clinical history, blood pressure readings, and biochemical parameters were collected and analyzed using SPSS version 26.0. The prevalence of microalbuminuria in the study population was found to be 57.7%. Microalbuminuria was significantly associated with higher systolic and diastolic blood pressures. Age, gender, and body mass index showed no significant correlation with the presence of microalbuminuria. The study reveals a high prevalence of microalbuminuria among patients with essential hypertension in a tertiary care setting. Regular screening for microalbuminuria in hypertensive patients is recommended for early detection and management to prevent progression to overt renal disease and reduce cardiovascular risks.

摘要

微量白蛋白尿是提示肾脏损害的早期标志物,已知可预测原发性高血压患者的心血管发病率和死亡率。然而,关于三级医疗中心高血压患者微量白蛋白尿患病率的研究有限。本研究旨在确定一家三级医疗中心原发性高血压患者微量白蛋白尿的患病率,并评估其与人口统计学和临床参数的关联。在一家三级医疗机构开展了一项横断面研究,纳入362例诊断为原发性高血压的患者。该研究采用随机尿样评估微量白蛋白尿,通过白蛋白与肌酐比值进行测量。收集涵盖患者人口统计学、临床病史、血压读数和生化参数的数据,并使用SPSS 26.0版进行分析。研究人群中微量白蛋白尿的患病率为57.7%。微量白蛋白尿与较高的收缩压和舒张压显著相关。年龄、性别和体重指数与微量白蛋白尿的存在无显著相关性。该研究揭示了三级医疗环境中原发性高血压患者微量白蛋白尿的高患病率。建议对高血压患者定期筛查微量白蛋白尿,以便早期发现和管理,防止进展为显性肾病并降低心血管风险。

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