• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

尼泊尔三级医疗中心原发性高血压患者微量白蛋白尿的患病率及其临床关联:一项横断面研究。

Prevalence and clinical correlates of microalbuminuria among patients of essential hypertension in tertiary care center of Nepal: A cross-sectional study.

作者信息

Lamsal Lekhnath, Joshi Rinku, Bhattarai Madhur, Parajuli Bibek, Timilsina Sunil, Kunwor Bishal, Chhetri Suchit, Bhandari Sujata, Chaurel Ashish, Bhattarai Himal Bikram

机构信息

Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.

Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.

出版信息

Medicine (Baltimore). 2025 Jun 27;104(26):e43075. doi: 10.1097/MD.0000000000043075.

DOI:10.1097/MD.0000000000043075
PMID:40587706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12212784/
Abstract

Microalbuminuria is an early marker indicating renal damage and is known to predict cardiovascular morbidity and mortality in individuals with essential hypertension. However, research on the prevalence of microalbuminuria among hypertensive patients attending tertiary care centers is limited. This study aims to determine the prevalence of microalbuminuria among patients with essential hypertension in a tertiary care center and to evaluate its association with demographic and clinical parameters. A cross-sectional research study was conducted at a tertiary care facility, involving 362 patients diagnosed with essential hypertension. The study utilized a spot urine sample to assess microalbuminuria, measured by the albumin-to-creatinine ratio. Data encompassing patient demographics, clinical history, blood pressure readings, and biochemical parameters were collected and analyzed using SPSS version 26.0. The prevalence of microalbuminuria in the study population was found to be 57.7%. Microalbuminuria was significantly associated with higher systolic and diastolic blood pressures. Age, gender, and body mass index showed no significant correlation with the presence of microalbuminuria. The study reveals a high prevalence of microalbuminuria among patients with essential hypertension in a tertiary care setting. Regular screening for microalbuminuria in hypertensive patients is recommended for early detection and management to prevent progression to overt renal disease and reduce cardiovascular risks.

摘要

微量白蛋白尿是提示肾脏损害的早期标志物,已知可预测原发性高血压患者的心血管发病率和死亡率。然而,关于三级医疗中心高血压患者微量白蛋白尿患病率的研究有限。本研究旨在确定一家三级医疗中心原发性高血压患者微量白蛋白尿的患病率,并评估其与人口统计学和临床参数的关联。在一家三级医疗机构开展了一项横断面研究,纳入362例诊断为原发性高血压的患者。该研究采用随机尿样评估微量白蛋白尿,通过白蛋白与肌酐比值进行测量。收集涵盖患者人口统计学、临床病史、血压读数和生化参数的数据,并使用SPSS 26.0版进行分析。研究人群中微量白蛋白尿的患病率为57.7%。微量白蛋白尿与较高的收缩压和舒张压显著相关。年龄、性别和体重指数与微量白蛋白尿的存在无显著相关性。该研究揭示了三级医疗环境中原发性高血压患者微量白蛋白尿的高患病率。建议对高血压患者定期筛查微量白蛋白尿,以便早期发现和管理,防止进展为显性肾病并降低心血管风险。

相似文献

1
Prevalence and clinical correlates of microalbuminuria among patients of essential hypertension in tertiary care center of Nepal: A cross-sectional study.尼泊尔三级医疗中心原发性高血压患者微量白蛋白尿的患病率及其临床关联:一项横断面研究。
Medicine (Baltimore). 2025 Jun 27;104(26):e43075. doi: 10.1097/MD.0000000000043075.
2
Systematic review on urine albumin testing for early detection of diabetic complications.关于尿白蛋白检测用于早期发现糖尿病并发症的系统评价。
Health Technol Assess. 2005 Aug;9(30):iii-vi, xiii-163. doi: 10.3310/hta9300.
3
Eplerenone for hypertension.依普利酮用于治疗高血压。
Cochrane Database Syst Rev. 2017 Feb 28;2(2):CD008996. doi: 10.1002/14651858.CD008996.pub2.
4
Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease.血管紧张素转换酶(ACE)抑制剂治疗镰状细胞病患者的蛋白尿和微量白蛋白尿。
Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD009191. doi: 10.1002/14651858.CD009191.pub4.
5
Altered dietary salt intake for preventing diabetic kidney disease and its progression.改变膳食盐摄入量以预防糖尿病肾病及其进展。
Cochrane Database Syst Rev. 2023 Jan 16;1(1):CD006763. doi: 10.1002/14651858.CD006763.pub3.
6
Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.高血压和心血管疾病患者的血压治疗目标。
Cochrane Database Syst Rev. 2022 Nov 18;11(11):CD010315. doi: 10.1002/14651858.CD010315.pub5.
7
Home treatment for mental health problems: a systematic review.心理健康问题的居家治疗:一项系统综述
Health Technol Assess. 2001;5(15):1-139. doi: 10.3310/hta5150.
8
Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term.孕34周直至足月时高血压疾病的计划早产与期待治疗对比
Cochrane Database Syst Rev. 2017 Jan 15;1(1):CD009273. doi: 10.1002/14651858.CD009273.pub2.
9
Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study.乌干达三级医院胎膜早破产妇的组织学绒毛膜羊膜炎及其预测因素:一项多中心横断面研究。
BMC Pregnancy Childbirth. 2025 Feb 6;25(1):128. doi: 10.1186/s12884-025-07245-4.
10
Length of stay and comorbidity prevalence among individuals with chronic obstructive pulmonary disease in a tertiary care healthcare center in Saudi Arabia; A cross-sectional study.沙特阿拉伯一家三级医疗保健中心慢性阻塞性肺疾病患者的住院时间和合并症患病率;一项横断面研究。
Medicine (Baltimore). 2025 May 23;104(21):e41855. doi: 10.1097/MD.0000000000041855.

本文引用的文献

1
Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease.蛋白尿:心血管疾病的一个被低估的风险因素。
J Am Heart Assoc. 2024 Jan 16;13(2):e030131. doi: 10.1161/JAHA.123.030131. Epub 2024 Jan 12.
2
Prevalence of Microalbuminuria in Patients of Essential Hypertension and its Correlation with Left Ventricular Hypertrophy and Carotid Artery Intima‑media Thickness.原发性高血压患者微量白蛋白尿的患病率及其与左心室肥厚和颈动脉内膜中层厚度的相关性
Kathmandu Univ Med J (KUMJ). 2022 Oct-Dec;20(80):417-421.
3
Microalbuminuria in Patients with Hypertension Visiting Tertiary Care Centre, Western Nepal.高血压患者在尼泊尔西部三级护理中心的微量白蛋白尿情况。
J Nepal Health Res Counc. 2021 Dec 14;19(3):530-535. doi: 10.33314/jnhrc.v19i3.3563.
4
Microalbuminuria Constitutes a Clinical Action Item for Clinicians in 2021.微量白蛋白尿在 2021 年构成了临床医生的临床行动项目。
Am J Med. 2022 May;135(5):576-580. doi: 10.1016/j.amjmed.2021.11.019. Epub 2021 Dec 31.
5
Microalbuminuria and cardiorenal risk: old and new evidence in different populations.微量白蛋白尿与心肾风险:不同人群中的新旧证据
F1000Res. 2019 Sep 19;8. doi: 10.12688/f1000research.17212.1. eCollection 2019.
6
2. Classification and Diagnosis of Diabetes: .2. 糖尿病的分类和诊断: 。
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27. doi: 10.2337/dc18-S002.
7
The prevalence, characteristics, and clinical significance of abnormal albuminuria in patients with hypertension.高血压患者白蛋白尿异常的患病率、特征及临床意义。
Sci Rep. 2014 Jan 24;4:3884. doi: 10.1038/srep03884.
8
Prevalence and association of microalbuminuria in essential hypertensive patients.原发性高血压患者微量白蛋白尿的患病率及相关性
N Am J Med Sci. 2012 Aug;4(8):331-5. doi: 10.4103/1947-2714.99501.
9
Prevalence of microalbuminuria in hypertensive patients and its associated cardiovascular risk in clinical cardiology: Moroccan results of the global i-SEARCH survey - a sub-analysis of a survey with 21,050 patients in 26 countries worldwide.临床心脏病学中高血压患者微量白蛋白尿的患病率及其相关心血管风险:全球i-SEARCH调查的摩洛哥结果——一项对全球26个国家21050名患者的调查的子分析
Cardiovasc J Afr. 2010 Jul-Aug;21(4):200-5. doi: 10.5830/cvja-2010-021.
10
Microalbuminuria and risk for cardiovascular disease: Analysis of potential mechanisms.微量白蛋白尿与心血管疾病风险:潜在机制分析
J Am Soc Nephrol. 2006 Aug;17(8):2106-11. doi: 10.1681/ASN.2005121288. Epub 2006 Jul 6.