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15-PGDH inhibition preserves blood-brain barrier integrity and cognition.

作者信息

van Egmond Daisy M, Lygeroudi Anita, Kooij Gijs

机构信息

Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands.

Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam 1081 BT, The Netherlands.

出版信息

Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2511399122. doi: 10.1073/pnas.2511399122. Epub 2025 Jun 30.

DOI:10.1073/pnas.2511399122
PMID:40587805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12260550/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12260550/541c45b00942/pnas.2511399122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12260550/541c45b00942/pnas.2511399122fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12260550/541c45b00942/pnas.2511399122fig01.jpg

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本文引用的文献

1
Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.抑制15-前列腺素脱氢酶可阻止血脑屏障退化，并保护小鼠免受阿尔茨海默病和创伤性脑损伤的影响。
Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2417224122. doi: 10.1073/pnas.2417224122. Epub 2025 May 21.
2
Spatial mapping of the AA-PGE-EP axis in multiple sclerosis lesions.多发性硬化症病变中AA-PGE-EP轴的空间映射。
Acta Neuropathol. 2025 Apr 29;149(1):39. doi: 10.1007/s00401-025-02878-3.
3
HPGD: An Intermediate Player in Microglial Polarization and Multiple Sclerosis Regulated by Nr4a1.
HPGD：由Nr4a1调控的小胶质细胞极化和多发性硬化中的中间作用因子
Mol Neurobiol. 2025 Jan;62(1):271-287. doi: 10.1007/s12035-024-04280-8. Epub 2024 Jun 6.
4
Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?花生四烯酸衍生的脂质介质在多发性硬化症发病机制中的作用：促进还是抑制疾病进展？
J Neuroinflammation. 2024 Jan 17;21(1):21. doi: 10.1186/s12974-023-02981-w.
5
Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.15-PGDH 的小分子抑制剂利用了一种生理性诱导契合关闭系统。
Nat Commun. 2023 Feb 11;14(1):784. doi: 10.1038/s41467-023-36463-7.
6
Harnessing prostaglandin E signaling to ameliorate autoimmunity.利用前列腺素 E 信号转导来改善自身免疫。
Trends Immunol. 2023 Mar;44(3):162-171. doi: 10.1016/j.it.2023.01.004. Epub 2023 Jan 25.
7
Recent advances in studies of 15-PGDH as a key enzyme for the degradation of prostaglandins.15-PGDH 作为降解前列腺素的关键酶的研究进展。
Int Immunopharmacol. 2021 Dec;101(Pt B):108176. doi: 10.1016/j.intimp.2021.108176. Epub 2021 Oct 13.
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Alzheimer's disease.阿尔茨海默病。
Lancet. 2021 Apr 24;397(10284):1577-1590. doi: 10.1016/S0140-6736(20)32205-4. Epub 2021 Mar 2.
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The Role of Sphingolipids and Specialized Pro-Resolving Mediators in Alzheimer's Disease.鞘脂类和专门的促解决介质在阿尔茨海默病中的作用。
Front Immunol. 2021 Jan 29;11:620348. doi: 10.3389/fimmu.2020.620348. eCollection 2020.
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