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15-PGDH inhibition preserves blood-brain barrier integrity and cognition.15-前列腺素脱氢酶抑制可维持血脑屏障完整性并改善认知。
Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2511399122. doi: 10.1073/pnas.2511399122. Epub 2025 Jun 30.
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Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.抑制15-前列腺素脱氢酶可阻止血脑屏障退化，并保护小鼠免受阿尔茨海默病和创伤性脑损伤的影响。
Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2417224122. doi: 10.1073/pnas.2417224122. Epub 2025 May 21.
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Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.mTOR 抑制可保护阿尔茨海默病和血管性认知障碍模型中的血脑屏障。
Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H693-H703. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22.
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Inhibition of HSP90 Preserves Blood-Brain Barrier Integrity after Cortical Spreading Depression.抑制热休克蛋白90可在皮层扩散性抑制后维持血脑屏障完整性。
Pharmaceutics. 2022 Aug 10;14(8):1665. doi: 10.3390/pharmaceutics14081665.
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Intranasal delivery of temozolomide and desloratadine for brain tumour therapy: A cellular study on nasal epithelial toxicity, transport, and permeability.替莫唑胺和地氯雷他定经鼻给药用于脑肿瘤治疗：关于鼻上皮毒性、转运和通透性的细胞研究
J Pharm Sci. 2025 Jul;114(7):103795. doi: 10.1016/j.xphs.2025.103795. Epub 2025 Apr 14.
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Inhibition of 15-hydroxyprostaglandin dehydrogenase protects neurons from ferroptosis in ischemic stroke.抑制15-羟基前列腺素脱氢酶可保护神经元免受缺血性脑卒中中的铁死亡。
MedComm (2020). 2024 Jan 7;5(1):e452. doi: 10.1002/mco2.452. eCollection 2024 Jan.
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Blood-Brain Barrier Dysfunction in Adults With Heart Failure.成人心力衰竭患者的血脑屏障功能障碍
J Neuroimaging. 2025 Jul-Aug;35(4):e70068. doi: 10.1111/jon.70068.
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ErbB4 Preserves Blood-Brain Barrier Integrity via the YAP/PIK3CB Pathway After Subarachnoid Hemorrhage in Rats.大鼠蛛网膜下腔出血后，ErbB4通过YAP/PIK3CB途径维持血脑屏障完整性。
Front Neurosci. 2018 Jul 24;12:492. doi: 10.3389/fnins.2018.00492. eCollection 2018.
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15-PGDH inhibition enhances hematopoietic regeneration during aging.15-前列腺素脱氢酶抑制可增强衰老过程中的造血再生。
Stem Cells. 2025 Jul 3. doi: 10.1093/stmcls/sxaf047.
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Luminal Vascular Dysfunction Drives Rapid Blood Brain Barrier Injury in Hyperglycemic Stroke: Key Roles for Luminal Glycocalyx and Complement.管腔血管功能障碍促使高血糖性卒中时血脑屏障快速损伤：管腔糖萼和补体的关键作用
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本文引用的文献
1
Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.抑制15-前列腺素脱氢酶可阻止血脑屏障退化，并保护小鼠免受阿尔茨海默病和创伤性脑损伤的影响。
Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2417224122. doi: 10.1073/pnas.2417224122. Epub 2025 May 21.
2
Spatial mapping of the AA-PGE-EP axis in multiple sclerosis lesions.多发性硬化症病变中AA-PGE-EP轴的空间映射。
Acta Neuropathol. 2025 Apr 29;149(1):39. doi: 10.1007/s00401-025-02878-3.
3
HPGD: An Intermediate Player in Microglial Polarization and Multiple Sclerosis Regulated by Nr4a1.HPGD：由Nr4a1调控的小胶质细胞极化和多发性硬化中的中间作用因子
Mol Neurobiol. 2025 Jan;62(1):271-287. doi: 10.1007/s12035-024-04280-8. Epub 2024 Jun 6.
4
Arachidonic acid-derived lipid mediators in multiple sclerosis pathogenesis: fueling or dampening disease progression?花生四烯酸衍生的脂质介质在多发性硬化症发病机制中的作用：促进还是抑制疾病进展？
J Neuroinflammation. 2024 Jan 17;21(1):21. doi: 10.1186/s12974-023-02981-w.
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Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.15-PGDH 的小分子抑制剂利用了一种生理性诱导契合关闭系统。
Nat Commun. 2023 Feb 11;14(1):784. doi: 10.1038/s41467-023-36463-7.
6
Harnessing prostaglandin E signaling to ameliorate autoimmunity.利用前列腺素 E 信号转导来改善自身免疫。
Trends Immunol. 2023 Mar;44(3):162-171. doi: 10.1016/j.it.2023.01.004. Epub 2023 Jan 25.
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Recent advances in studies of 15-PGDH as a key enzyme for the degradation of prostaglandins.15-PGDH 作为降解前列腺素的关键酶的研究进展。
Int Immunopharmacol. 2021 Dec;101(Pt B):108176. doi: 10.1016/j.intimp.2021.108176. Epub 2021 Oct 13.
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Alzheimer's disease.阿尔茨海默病。
Lancet. 2021 Apr 24;397(10284):1577-1590. doi: 10.1016/S0140-6736(20)32205-4. Epub 2021 Mar 2.
9
The Role of Sphingolipids and Specialized Pro-Resolving Mediators in Alzheimer's Disease.鞘脂类和专门的促解决介质在阿尔茨海默病中的作用。
Front Immunol. 2021 Jan 29;11:620348. doi: 10.3389/fimmu.2020.620348. eCollection 2020.
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Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.抑制前列腺素降解酶 15-PGDH 可恢复衰老肌肉的质量和力量。
Science. 2021 Jan 29;371(6528). doi: 10.1126/science.abc8059. Epub 2020 Dec 10.
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