Jancsó G, Király E, Joó F, Such G, Nagy A
Neurosci Lett. 1985 Aug 30;59(2):209-14. doi: 10.1016/0304-3940(85)90201-0.
The morphological effects of systemic capsaicin treatment have been studied in adult rats. Light and electron microscopy revealed that a subpopulation of small-to-medium sized B-type primary sensory neurons, representing about 17% of the total neuronal population in the 4th lumbar spinal ganglion, underwent rapid degeneration after the administration of capsaicin. Quantitative electron microscopy demonstrated a decrease of about 45% in the number of unmyelinated axons in the saphenous nerve. Light microscopy showed extensive axon terminal degeneration in the brainstem and spinal cord confined to the central projection areas of capsaicin-sensitive afferent fibers, as has already been revealed in the newborn rat. The present results furnish evidence for a hitherto unrecognized selective neurodegenerative action of capsaicin in the adult rat.
已经在成年大鼠中研究了全身辣椒素治疗的形态学效应。光镜和电镜检查显示，第4腰脊髓神经节中占神经元总数约17%的中小尺寸B型初级感觉神经元亚群，在给予辣椒素后迅速退化。定量电镜显示隐神经中无髓轴突数量减少约45%。光镜显示脑干和脊髓中广泛的轴突终末变性，局限于辣椒素敏感传入纤维的中枢投射区域，这在新生大鼠中已得到证实。目前的结果为辣椒素在成年大鼠中迄今未被认识的选择性神经退行性作用提供了证据。
