Bencsik Péter, Gömöri Kamilla, Szabados Tamara, Sántha Péter, Helyes Zsuzsanna, Jancsó Gábor, Ferdinandy Péter, Görbe Anikó
Cardiovascular Research Group, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Pharmahungary Group, Szeged, Hungary.
Br J Pharmacol. 2020 Dec;177(23):5336-5356. doi: 10.1111/bph.15021. Epub 2020 Mar 21.
During the last decades, mortality from acute myocardial infarction has been dramatically reduced. However, the incidence of post-infarction heart failure is still increasing. Cardioprotection by ischaemic conditioning had been discovered more than three decades ago. Its clinical translation, however, is still an unmet need. This is mainly due to the disrupted cardioprotective signalling pathways in the presence of different cardiovascular risk factors, co-morbidities and the medication being taken. Sensory neuropathy is one of the co-morbidities that has been shown to interfere with cardioprotection. In the present review, we summarize the diverse aetiology of sensory neuropathies and the mechanisms by which these neuropathies may interfere with ischaemic heart disease and cardioprotective signalling. Finally, we suggest future therapeutic options targeting both ischaemic heart and sensory neuropathy simultaneously. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc.
在过去几十年中，急性心肌梗死的死亡率已大幅降低。然而，心肌梗死后心力衰竭的发病率仍在上升。缺血预处理的心脏保护作用早在三十多年前就已被发现。然而，其临床应用仍未得到满足。这主要是由于在存在不同心血管危险因素、合并症和正在服用的药物的情况下，心脏保护信号通路受到干扰。感觉神经病变是已被证明会干扰心脏保护作用的合并症之一。在本综述中，我们总结了感觉神经病变的多种病因以及这些神经病变可能干扰缺血性心脏病和心脏保护信号的机制。最后，我们提出了同时针对缺血性心脏病和感觉神经病变的未来治疗选择。相关文章：本文是关于心脏保护中的危险因素、合并症和协同用药的主题问题的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc。
