Cruz T F, Quackenbush E J, Letarte M, Moscarello M A
Neurosci Lett. 1985 Sep 6;59(3):253-7. doi: 10.1016/0304-3940(85)90140-5.
The concentration of a glycoprotein reactive with monoclonal antibody 44D10 was studied during development and aging in 19 normal brains. Little change in the concentration of the antigen was found in white matter of brains ranging from the age of 1 to 54 years. However, a linear increase in the concentration of antigen was observed between the ages of 54 and 80 years. By the age of 80 years, the concentration of the glycoprotein had increased 2-3-fold. In contrast to white matter, gray matter did not contain detectable levels of antigen at ages from 1 to 54 years. Low levels of antigen were detected in brains of all older individuals examined. However, the relative concentration of this glycoprotein in gray matter was less than 5% of that in white matter. An examination of white matter homogenates from guinea pig and bovine brain showed that monoclonal antibody 44D10 was not reactive in these species.
在19个正常大脑的发育和衰老过程中，研究了与单克隆抗体44D10反应的糖蛋白浓度。在1至54岁的大脑白质中，未发现抗原浓度有明显变化。然而，在54至80岁之间，观察到抗原浓度呈线性增加。到80岁时，糖蛋白浓度增加了2至3倍。与白质相反，在1至54岁时，灰质中未检测到可检测水平的抗原。在所有检查的老年个体的大脑中都检测到了低水平的抗原。然而，这种糖蛋白在灰质中的相对浓度不到白质中的5%。对豚鼠和牛脑白质匀浆的检查表明，单克隆抗体44D10在这些物种中无反应。
