Aronoff Jacob E, Jenkins Carrie L, Garcia Angela R, Koebele Stephanie V, Ghafoor Suhail, Woolard Kate L, Charifson Mia, Suarez Ivan M, Eid Rodriguez Daniel, Beheim Bret, Cummings Daniel K, Hooper Paul L, Kraft Thomas K, Buetow Kenneth, Finch Caleb E, Franck Maximilien, Cohen Alan A, Stieglitz Jonathan, Gurven Michael, Kaplan Hillard, Trumble Benjamin C
School of Human Evolution and Social Change; Center for Evolution and Medicine; Institute for Human Origins, Arizona State University, Tempe, AZ, USA.
School of Life Sciences; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.
Proc Biol Sci. 2025 Aug;292(2053):20251111. doi: 10.1098/rspb.2025.1111. Epub 2025 Aug 20.
An increase in chronic systemic inflammation in later life, termed inflammaging, is implicated in health risk. However, it is unclear whether inflammaging develops in all human populations, or if it is the product of environmental mismatch. We assessed inflammaging in Tsimane forager-horticulturalists of the Bolivian Amazon, using serum cytokines in a primarily cross-sectional sample (1134 samples from = 714 individuals, age 39-94, 51.3% female). IL-6 was positively associated with age ( = 0.013, < 0.01). However, other pro-inflammatory markers, including IL-1β and TNF-α, did not increase with age ( = -0.005 and = -0.001, respectively). We then compared the Moseten, a neighbouring population that has experienced greater market integration (423 samples from = 380 individuals, age 39-85, 48.2% female). The Moseten also showed a positive age association for IL-6 that attenuated at later ages (age = 0.025, < 0.01; age = -0.001, < 0.05). Further, IL-1β and TNF-α were both positively associated with age ( = 0.021, < 0.05 and = 0.011, < 0.01, respectively). Our results demonstrate minimal inflammaging in the Tsimane, highlighting variation across populations in this age-related process. They also suggest that inflammaging is exacerbated by lifestyle shifts.
晚年慢性全身性炎症的增加，即所谓的炎症衰老，与健康风险相关。然而，目前尚不清楚炎症衰老是否在所有人群中都会出现，或者它是否是环境不匹配的产物。我们对玻利维亚亚马逊地区的齐曼内觅食-园艺人群的炎症衰老进行了评估，在一个主要为横断面的样本中（来自714名个体的1134份样本，年龄39 - 94岁，女性占51.3%）使用血清细胞因子。白细胞介素-6（IL - 6）与年龄呈正相关（β = 0.013，P < 0.01）。然而，其他促炎标志物，包括白细胞介素-1β（IL - 1β）和肿瘤坏死因子-α（TNF - α），并未随年龄增加（分别为β = -0.005和β = -0.001）。然后，我们比较了莫塞滕人，这是一个经历了更大程度市场融合的相邻人群（来自380名个体的423份样本，年龄39 - 85岁，女性占48.2%）。莫塞滕人也显示出IL - 6与年龄呈正相关，且在较高年龄时减弱（年龄β = 0.025，P < 0.01；年龄β = -0.001，P < 0.
