Hassabi Mohammad, Hasani Mohammad, Khodabakhshian Shaghayegh, Javanbakht Mohammad, Aliakbar Shiva, Movahedi Alireza, Ghorbani Helia, Mohebbi Mahdi, Movahedi Hamidreza, Nodoushan Mohamad Hosein Tabatabaei, Mirani Abolfazl
Department of Sports and Exercise Medicine, Taleghani hospital Research Development committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of General Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Cardiothorac Surg. 2025 Jul 1;20(1):280. doi: 10.1186/s13019-025-03479-7.
Peripheral Arterial Disease (PAD) is a global health concern, particularly among aging populations. While previous studies have examined various aspects of PAD, the role of ankle muscle strength and endurance in assessing ischemia severity remains underexplored. This study investigates the relationship between ankle dorsiflexion and plantar flexion strength and ischemia severity in PAD patients.
This cross-sectional observational study included 53 PAD patients with chronic limb ischemia confirmed via angiography. Mean age was 64.5 years, and the majority were male. Ankle muscle strength was measured using a custom-designed hand-held dynamometer, which underwent internal validation and reliability testing before implementation. Spearman's correlation and multiple regression models assessed the association between muscle function and ischemia severity.
A significant positive correlation was found between dorsiflexion/plantar flexion strength and ischemia severity one-month post-intervention (Spearman's rho = 0.35, P = 0.015; Spearman's rho = 0.40, P = 0.010). Pre-intervention assessments established a baseline correlation, allowing evaluation of ischemia progression and its impact on muscle function.
Our data showed that ankle strength assessments may serve as predictive markers for ischemia severity in PAD patients. Implementing these measurements in clinical practice could enhance treatment optimization and patient outcomes.
外周动脉疾病（PAD）是一个全球关注的健康问题，在老年人群中尤为突出。虽然先前的研究已经探讨了PAD的各个方面，但踝关节肌肉力量和耐力在评估缺血严重程度中的作用仍未得到充分研究。本研究调查了PAD患者踝关节背屈和跖屈力量与缺血严重程度之间的关系。
这项横断面观察性研究纳入了53例经血管造影确诊为慢性肢体缺血的PAD患者。平均年龄为64.5岁，大多数为男性。使用定制设计的手持式测力计测量踝关节肌肉力量，该测力计在使用前进行了内部验证和可靠性测试。Spearman相关性分析和多元回归模型评估了肌肉功能与缺血严重程度之间的关联。
干预后1个月，背屈/跖屈力量与缺血严重程度之间存在显著正相关（Spearman相关系数ρ = 0.35，P = 0.015；Spearman相关系数ρ = 0.40，P = 0.010）。干预前评估建立了基线相关性，从而能够评估缺血进展及其对肌肉功能的影响。
我们的数据表明，踝关节力量评估可能作为PAD患者缺血严重程度的预测指标。在临床实践中进行这些测量可以优化治疗并改善患者预后。
