Peiffer R L, Werblin T P, Fryczkowski A W
Ophthalmology. 1985 Sep;92(9):1294-304. doi: 10.1016/s0161-6420(85)33869-1.
Hydrogel keratophakia is a new form of lamellar refractive surgery which, in theory, can deal with almost all forms of refractive error. We examined the histopathological effects of several types of hydrogel materials on the cornea of non-human primates. With the exception of one type of hydrogel material, which was associated with endothelial cell degeneration, only minor histopathologic changes were seen up to a maximum of one year of observation, including thinning of the epithelium and decreased population of stromal keratocytes. These changes did not correlate with any clinical abnormalities. Additional extensive preclinical testing and eventual human clinical trials will determine the safety and efficacy of this procedure.
水凝胶角膜屈光成形术是一种新型的板层屈光手术，理论上可以处理几乎所有类型的屈光不正。我们研究了几种水凝胶材料对非人灵长类动物角膜的组织病理学影响。除了一种与内皮细胞变性相关的水凝胶材料外，在长达一年的观察期内，仅观察到轻微的组织病理学变化，包括上皮变薄和基质角膜细胞数量减少。这些变化与任何临床异常均无关联。进一步广泛的临床前测试以及最终的人体临床试验将确定该手术的安全性和有效性。
