Werblin T P, Fryczkowski A W, Peiffer R L
Ann Ophthalmol. 1984 Dec;16(12):1127-30.
Hydrogel keratophakia has been studied in a non-primate model in an attempt to develop a more predictable form of myopic refractive surgery. Although the largest potential clinical use for this form of surgery is for the correction of myopia, currently available surgical techniques are not nearly as predictable as non-surgical devices such as spectacles and contact lenses. In this paper, hydrogel lenses, implanted in non-human primate corneas, were used for the first time to flatten the anterior corneal surface as would be required for the correction of myopia. Up to 9 diopters of correction was obtained. Little change in corneal astigmatism was found. The technical aspects of the surgery are quite simple, and the corneas healed rapidly and have excellent clarity. Extensive primate testing will be necessary to determine the accuracy of this procedure before clinical trials should be undertaken.
水凝胶角膜屈光术已在非灵长类动物模型中进行了研究，旨在开发一种更可预测的近视屈光手术形式。尽管这种手术形式最大的潜在临床用途是矫正近视，但目前可用的手术技术远不如眼镜和隐形眼镜等非手术器械那样可预测。在本文中，首次将植入非人类灵长类动物角膜的水凝胶镜片用于使角膜前表面变平，这是矫正近视所必需的。获得了高达9屈光度的矫正效果。发现角膜散光变化很小。手术的技术方面相当简单，角膜愈合迅速且透明度极佳。在进行临床试验之前，需要进行广泛的灵长类动物测试以确定该手术的准确性。
