Przy Rebecca, Wade Mira M M, Welter Priscilla G, Brocardo Patricia S, Christie Brian R
Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
School of Medicine, University College Dublin, Dublin, Ireland.
J Comp Neurol. 2025 Jul;533(7):e70069. doi: 10.1002/cne.70069.
The lateral entorhinal cortex (LEC) projections to the hippocampus (HC) play a critical role in cognition and have been associated with cognitive impairments related to aging and neurodegenerative disease. This review aims to provide a detailed anatomical description of the LEC-to-HC pathway, based on a review of data collected using neuroanatomical tract tracing techniques. The LEC projects to the HC in a layer-specific manner. Layer II of the LEC provides the primary source of projections to the dentate gyrus (DG), while layer III is the primary source of projections to the subiculum and cornu Ammonis (CA) region. These projections terminate in the molecular layers of the HC and follow a topographical distribution along the dorsolateral-ventromedial axis. Having a clear understanding of the LEC-to-HC pathway is essential background for investigating its functions and alterations due to disease and aging processes.
内嗅皮质外侧区（LEC）向海马体（HC）的投射在认知中起关键作用，并与衰老和神经退行性疾病相关的认知障碍有关。本综述旨在基于对使用神经解剖学示踪技术收集的数据的回顾，提供LEC至HC通路的详细解剖学描述。LEC以层特异性方式投射至HC。LEC的第二层是投射至齿状回（DG）的主要来源，而第三层是投射至下托和海马角（CA）区域的主要来源。这些投射终止于HC的分子层，并沿背外侧 - 腹内侧轴呈拓扑分布。清楚了解LEC至HC通路是研究其功能以及疾病和衰老过程导致的改变的重要背景知识。
