Kamezaki Hidehiro, Iwanaga Terunao, Maeda Takahiro, Senoo Junichi, Ohyama Hiroshi, Kato Naoya, Sugiura Nobuyuki
Department of Gastroenterology Eastern Chiba Medical Center Togane Chiba Japan.
Department of Gastroenterology Graduate School of Medicine, Chiba University Chiba Chiba Japan.
JGH Open. 2025 Jun 29;9(7):e70214. doi: 10.1002/jgh3.70214. eCollection 2025 Jul.
We aimed to evaluate the risk of pseudogallstones and biliary tract infections after ceftriaxone administration in patients undergoing rehabilitation.
This retrospective observational study was conducted from October 2016 to May 2022. During this period, 41 patients with gastrointestinal and hepatobiliary conditions were transferred from a rehabilitation hospital to an acute care facility. Of these, 22 patients were diagnosed with biliary tract infections, and they were included in the study. Data collection focused on patient demographics, antibiotic history, incidence of pseudogallstones, and related biliary complications. The median patient age was 83.5 years, with 45.5% male and 54.5% female patients. The primary reasons for rehabilitation included orthopedic and neurological diseases. A history of antibiotic administration was noted in 63.6% of patients, with 18.2% developing pseudogallstones after ceftriaxone administration. Individual case studies highlighted acute cholangitis and biliary sludge formation following ceftriaxone therapy.
This study identified a significant incidence of pseudogallstones and biliary complications associated with ceftriaxone administration, particularly in elderly patients, patients with immobility, and those with renal impairment. By using ceftriaxone in appropriate patients, the number of patients with biliary tract infections transferred from rehabilitation hospitals to acute-care hospitals can be reduced by 18.2%, thereby improving patient outcomes in rehabilitation settings.
我们旨在评估康复患者使用头孢曲松后出现假胆结石和胆道感染的风险。
本回顾性观察研究于2016年10月至2022年5月进行。在此期间，41例胃肠道和肝胆疾病患者从康复医院转入急性护理机构。其中，22例被诊断为胆道感染，并纳入研究。数据收集集中在患者人口统计学、抗生素使用史、假胆结石发病率及相关胆道并发症。患者中位年龄为83.5岁，男性占45.5%，女性占54.5%。康复的主要原因包括骨科和神经疾病。63.6%的患者有抗生素使用史，18.2%的患者在使用头孢曲松后出现假胆结石。个别病例研究突出了头孢曲松治疗后急性胆管炎和胆泥形成。
本研究发现与使用头孢曲松相关的假胆结石和胆道并发症发生率较高，尤其是在老年患者、行动不便患者和肾功能损害患者中。通过在合适的患者中使用头孢曲松，从康复医院转入急性护理医院的胆道感染患者数量可减少18.2%，从而改善康复环境中的患者预后。
