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膳食纤维摄入量与海马灰质体积：一项针对健康成年人的探索性横断面研究。

Dietary fiber intake and hippocampal gray matter volume: an exploratory cross-sectional study in healthy adults.

作者信息

Pallapothu Raghav, Newman-Norlund Roger D, Gibson Makayla, Kannan Pranesh Rajesh, Pallapothu Sriya, Rorden Chris, Bonilha Leonardo, Fridriksson Julius

机构信息

Department of Psychology, College of Arts and Sciences, University of South Carolina, Columbia, SC, United States.

Department of Neurology, School of Medicine, University of South Carolina, Columbia, SC, United States.

出版信息

Front Nutr. 2025 Jun 16;12:1608995. doi: 10.3389/fnut.2025.1608995. eCollection 2025.

DOI:10.3389/fnut.2025.1608995
PMID:40589779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12206789/
Abstract

INTRODUCTION

Alzheimer's disease and related dementia (ADRD) are associated with significance societal costs and economic burdens. Prior research has found that ADRD is associated with decreases in cortical gray matter volume (GMV) in the hippocampus.

METHODS

This exploratory cross-sectional study investigates the relationship between total dietary fiber concentration and regional GMV in a cohort of 190 healthy adults aged 20 to 79 years who completed the 2015 National Health Interview Survey Supplement and T1-weighted magnetic resonance imaging (MRI) as part of the University of South Carolina's Aging Brain Cohort (ABC) study. Hippocampal gray matter volume was quantified using the CAT12 voxel-based morphometry toolbox, using Spearman's rank order correlation coefficient.

RESULTS

Our exploratory analysis revealed a significant positive correlation between dietary fiber consumption and GMV in the right hippocampus and right parahippocampal gyrus, when controlling for age, race, sex, and median household income within participant zip code. Dietary fiber was also correlated with the MoCA attention/concentration and language subscores.

DISCUSSION

These data are compatible with the hypothesis that dietary fiber may exert neuroprotective effects, and this may have implications for dietary recommendations aimed at reducing the risk of Alzheimer's disease and related dementias.

摘要

引言

阿尔茨海默病及相关痴呆症（ADRD）会带来巨大的社会成本和经济负担。先前的研究发现，ADRD与海马体皮质灰质体积（GMV）减少有关。

方法

这项探索性横断面研究调查了190名年龄在20至79岁之间的健康成年人队列中膳食纤维总浓度与区域GMV之间的关系，这些成年人完成了2015年国家健康访谈调查补充问卷以及作为南卡罗来纳大学衰老大脑队列（ABC）研究一部分的T1加权磁共振成像（MRI）。使用CAT12基于体素的形态计量学工具箱，通过斯皮尔曼等级相关系数对海马体灰质体积进行量化。

结果

在控制参与者邮政编码内的年龄、种族、性别和家庭收入中位数后，我们的探索性分析显示，膳食纤维摄入量与右侧海马体和右侧海马旁回的GMV之间存在显著正相关。膳食纤维还与蒙特利尔认知评估量表（MoCA）的注意力/专注力和语言子分数相关。

讨论

这些数据与膳食纤维可能发挥神经保护作用的假设相符，这可能对旨在降低阿尔茨海默病及相关痴呆症风险的饮食建议具有启示意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/cc508e7abf15/fnut-12-1608995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/1b38d45e599b/fnut-12-1608995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/0ffee292a897/fnut-12-1608995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/8902af900544/fnut-12-1608995-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/cc508e7abf15/fnut-12-1608995-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/1b38d45e599b/fnut-12-1608995-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/0ffee292a897/fnut-12-1608995-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/8902af900544/fnut-12-1608995-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/3c0b855086d8/fnut-12-1608995-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df44/12206789/cc508e7abf15/fnut-12-1608995-g005.jpg

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本文引用的文献

1
The Aging Brain Cohort (ABC) repository: The University of South Carolina's multimodal lifespan database for studying the relationship between the brain, cognition, genetics and behavior in healthy aging.衰老大脑队列（ABC）数据库：南卡罗来纳大学的多模态寿命数据库，用于研究健康衰老过程中大脑、认知、基因与行为之间的关系。
Neuroimage Rep. 2021 Apr 21;1(1):100008. doi: 10.1016/j.ynirp.2021.100008. eCollection 2021 Mar.
2
CAT: a computational anatomy toolbox for the analysis of structural MRI data.CAT：用于分析结构磁共振成像数据的计算解剖工具箱。
Gigascience. 2024 Jan 2;13. doi: 10.1093/gigascience/giae049.
3
Serum short chain fatty acids mediate hippocampal BDNF and correlate with decreasing neuroinflammation following high pectin fiber diet in mice.
血清短链脂肪酸介导海马脑源性神经营养因子，并与小鼠高果胶纤维饮食后神经炎症的减轻相关。
Front Neurosci. 2023 Apr 11;17:1134080. doi: 10.3389/fnins.2023.1134080. eCollection 2023.
4
Dietary Fiber Intake is Associated with Cognitive Function in Older Adults: Data from the National Health and Nutrition Examination Survey.膳食纤维摄入量与老年人认知功能相关：来自国家健康和营养调查的数据。
Am J Med. 2022 Aug;135(8):e257-e262. doi: 10.1016/j.amjmed.2022.03.022. Epub 2022 Apr 1.
5
A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites.纤维缺乏饮食通过肠道微生物群和代谢物导致认知障碍和海马小胶质细胞介导的突触丢失。
Microbiome. 2021 Nov 11;9(1):223. doi: 10.1186/s40168-021-01172-0.
6
Grey Matter Loss at Different Stages of Cognitive Decline: A Role for the Thalamus in Developing Alzheimer's Disease.灰质在认知衰退不同阶段的损失：丘脑在阿尔茨海默病发展中的作用。
J Alzheimers Dis. 2021;83(2):705-720. doi: 10.3233/JAD-210173.
7
Dietary Fibre Modulates the Gut Microbiota.膳食纤维调节肠道菌群。
Nutrients. 2021 May 13;13(5):1655. doi: 10.3390/nu13051655.
8
How does hemispheric specialization contribute to human-defining cognition?大脑两半球特化如何促进人类特有的认知？
Neuron. 2021 Jul 7;109(13):2075-2090. doi: 10.1016/j.neuron.2021.04.024. Epub 2021 May 17.
9
Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis.顺着纹理走：纤维、认知和微生物群-肠-脑轴。
Exp Biol Med (Maywood). 2021 Apr;246(7):796-811. doi: 10.1177/1535370221995785. Epub 2021 Feb 28.
10
Sleep Duration, Sleep Apnea, and Gray Matter Volume.睡眠时长、睡眠呼吸暂停与灰质体积。
J Geriatr Psychiatry Neurol. 2022 Jan;35(1):47-56. doi: 10.1177/0891988720988918. Epub 2021 Jan 29.