• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿尼氟单抗成功用于治疗伴有系统性红斑狼疮的难治性皮肤红斑狼疮：一例报告。

Successful use of anifrolumab in refractory cutaneous lupus erythematosus with systemic lupus erythematosus: A case report.

作者信息

Ramadhan Abdullah, Troug Anita, Yacyshyn Elaine, Gniadecki Robert

机构信息

Department of Dermatology, University of Alberta, Edmonton, AB, Canada.

出版信息

SAGE Open Med Case Rep. 2025 Jun 29;13:2050313X251350376. doi: 10.1177/2050313X251350376. eCollection 2025.

DOI:10.1177/2050313X251350376
PMID:40589849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12206980/
Abstract

A 61-year-old female with systemic lupus erythematosus presented with refractory discoid lupus. Despite treatment with numerous immunosuppressive therapies, including prednisone, hydroxychloroquine and mycophenolate mofetil, her cutaneous lupus remained active and significantly impacted her quality of life. Introduction of anifrolumab led to remarkable improvement, highlighting its potential for refractory discoid lupus erythematosus.

摘要

一名61岁的系统性红斑狼疮女性患者出现难治性盘状狼疮。尽管接受了包括泼尼松、羟氯喹和霉酚酸酯在内的多种免疫抑制治疗，但其皮肤狼疮仍处于活动状态，严重影响了她的生活质量。阿尼鲁单抗的引入带来了显著改善，凸显了其在难治性盘状红斑狼疮中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a0/12206980/92915af6ced1/10.1177_2050313X251350376-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a0/12206980/e599fb659e19/10.1177_2050313X251350376-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a0/12206980/88e21b44a5bb/10.1177_2050313X251350376-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a0/12206980/92915af6ced1/10.1177_2050313X251350376-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a0/12206980/e599fb659e19/10.1177_2050313X251350376-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a0/12206980/88e21b44a5bb/10.1177_2050313X251350376-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45a0/12206980/92915af6ced1/10.1177_2050313X251350376-fig3.jpg

相似文献

1
Successful use of anifrolumab in refractory cutaneous lupus erythematosus with systemic lupus erythematosus: A case report.阿尼氟单抗成功用于治疗伴有系统性红斑狼疮的难治性皮肤红斑狼疮：一例报告。
SAGE Open Med Case Rep. 2025 Jun 29;13:2050313X251350376. doi: 10.1177/2050313X251350376. eCollection 2025.
2
Case series of anifrolumab for treatment of cutaneous lupus erythematosus and lupus-related mucocutaneous manifestations in patients with SLE.系统性红斑狼疮患者用阿尼鲁单抗治疗红斑狼疮皮疹和狼疮相关黏膜表现的病例系列
Lupus Sci Med. 2023 Dec 19;10(2):e001007. doi: 10.1136/lupus-2023-001007.
3
Role of Anifrolumab in Refractory Cutaneous Manifestations of Lupus Erythematosus: A Case Series and Literature Review.阿尼鲁单抗在红斑狼疮难治性皮肤表现中的作用：病例系列及文献综述
Cureus. 2023 May 27;15(5):e39553. doi: 10.7759/cureus.39553. eCollection 2023 May.
4
Progressive repigmentation of hypopigmented lesions in discoid lupus erythematosus with anifrolumab: A report of two cases.阿尼芬净治疗盘状红斑狼疮色素减退性皮损的渐进性色素再沉着：2例报告
Lupus. 2025 Jun;34(7):761-763. doi: 10.1177/09612033251345017. Epub 2025 May 16.
5
Drugs for discoid lupus erythematosus.用于盘状红斑狼疮的药物。
Cochrane Database Syst Rev. 2009 Oct 7(4):CD002954. doi: 10.1002/14651858.CD002954.pub2.
6
A case of vitiligo secondary to discoid lupus erythematosus treated with tofacitinib.1例盘状红斑狼疮继发白癜风患者接受托法替布治疗。
Medicine (Baltimore). 2025 Jun 27;104(26):e43118. doi: 10.1097/MD.0000000000043118.
7
Drugs for discoid lupus erythematosus.用于盘状红斑狼疮的药物。
Cochrane Database Syst Rev. 2001(1):CD002954. doi: 10.1002/14651858.CD002954.
8
Anifrolumab for refractory discoid lupus: Two case reports of successful outcomes in Saudi Arabia.阿尼鲁单抗治疗难治性盘状狼疮：沙特阿拉伯两例成功病例报告
Medicine (Baltimore). 2025 May 16;104(20):e42518. doi: 10.1097/MD.0000000000042518.
9
Drugs for discoid lupus erythematosus.用于盘状红斑狼疮的药物。
Cochrane Database Syst Rev. 2017 May 5;5(5):CD002954. doi: 10.1002/14651858.CD002954.pub3.
10
Long-term effect of anifrolumab on patient-reported outcomes in systemic lupus erythematosus (TULIP-LTE): a randomised, placebo-controlled, phase 3 long-term extension trial.阿尼芬净单抗对系统性红斑狼疮患者报告结局的长期影响（TULIP-LTE）：一项随机、安慰剂对照的3期长期扩展试验。
Lancet Rheumatol. 2025 Jul;7(7):e485-e494. doi: 10.1016/S2665-9913(25)00022-0. Epub 2025 May 2.

本文引用的文献

1
Treatment of discoid lupus with lenalidomide and anifrolumab: Case report and review of the literature.来那度胺和阿尼鲁单抗治疗盘状狼疮：病例报告及文献复习。
Lupus. 2024 Nov;33(13):1487-1491. doi: 10.1177/09612033241289489. Epub 2024 Oct 7.
2
Efficacy of anifrolumab in long-term intractable alopecia due to discoid lupus erythematosus.阿尼鲁单抗治疗盘状红斑狼疮所致长期难治性脱发的疗效。
Mod Rheumatol Case Rep. 2024 Jul 8;8(2):267-271. doi: 10.1093/mrcr/rxae018.
3
Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial.
I型干扰素抑制剂阿尼鲁单抗治疗活动性系统性红斑狼疮（TULIP-1）：一项随机、对照、3期试验
Lancet Rheumatol. 2019 Dec;1(4):e208-e219. doi: 10.1016/S2665-9913(19)30076-1. Epub 2019 Nov 11.
4
Case series of anifrolumab for treatment of cutaneous lupus erythematosus and lupus-related mucocutaneous manifestations in patients with SLE.系统性红斑狼疮患者用阿尼鲁单抗治疗红斑狼疮皮疹和狼疮相关黏膜表现的病例系列
Lupus Sci Med. 2023 Dec 19;10(2):e001007. doi: 10.1136/lupus-2023-001007.
5
Successful treatment of severe chronic cutaneous lupus with anifrolumab: A series of 6 cases.用阿尼氟单抗成功治疗重度慢性皮肤型狼疮：6例病例系列
JAAD Case Rep. 2023 May 4;37:21-29. doi: 10.1016/j.jdcr.2023.04.024. eCollection 2023 Jul.
6
Rapid efficacy of anifrolumab across multiple subtypes of recalcitrant cutaneous lupus erythematosus parallels changes in discrete subsets of blood transcriptomic and cellular biomarkers.阿尼鲁单抗在多种难治性皮肤红斑狼疮亚型中的快速疗效与血液转录组和细胞生物标志物离散亚群的变化平行。
Br J Dermatol. 2023 Jul 17;189(2):210-218. doi: 10.1093/bjd/ljad089.
7
Anifrolumab for treatment of refractory cutaneous lupus erythematosus.阿尼鲁单抗治疗难治性皮肤红斑狼疮。
Clin Exp Dermatol. 2022 Nov;47(11):1998-2001. doi: 10.1111/ced.15335. Epub 2022 Aug 26.
8
Current Insights Into The Management Of Discoid Lupus Erythematosus.盘状红斑狼疮治疗的最新见解
Clin Cosmet Investig Dermatol. 2019 Oct 3;12:721-732. doi: 10.2147/CCID.S184824. eCollection 2019.