Rossi Settimio, Gesualdo Carlo, Della Corte Michele, Del Giudice Antonio, Rosolia Andrea, Trotta Maria Consiglia, Simonelli Francesca
Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Front Med (Lausanne). 2025 Jun 16;12:1605391. doi: 10.3389/fmed.2025.1605391. eCollection 2025.
The use of vital dyes is essential for enhancing visualization of the vitreous and vitreoretinal interface during surgery. In this study, we evaluated the efficacy of a new lutein-based vital dye (LB-VD) for selective staining of the vitreous body and posterior hyaloid in patients undergoing 25 G vitrectomy for idiopathic epiretinal membrane (ERM).
A total of 18 patients who underwent ERM surgery assisted by LB-VD were retrospectively analyzed. The surgeon completed a postoperative satisfaction questionnaire to evaluate the vitreous staining. Data on best-corrected visual acuity (BCVA), central retinal thickness (CRT), intraocular pressure (IOP), and fixation stability were collected at baseline and at 4 and 6 months post-surgery.
LB-VD effectively stained the vitreous body and posterior hyaloid, facilitating key surgical maneuvers. Significant improvements were observed in BCVA and CRT at both 4 and 6 months post-surgery. Specifically, BCVA improved from 0.60 ± 0.29 LogMAR at baseline to 0.33 ± 0.26 LogMAR at 4 months ( = 0.004) and to 0.32 ± 0.25 LogMAR at 6 months ( = 0.003). CRT decreased significantly from 429 (375-499) μm at baseline to 335 (254-375) μm at 4 months ( = 0.03) and to 323 (240-356) μm at 6 months ( = 0.01). Fixation stability improved in approximately 95% of patients by 6 months. No significant changes in IOP were noted.
LB-VD provided clear visualization of the vitreous body and posterior hyaloid, thereby facilitating key vitreoretinal surgical tasks. These findings suggest that LB-VD is an effective and safe alternative to traditional dyes currently used in vitreoretinal surgery.
在手术过程中使用活性染料对于增强玻璃体和玻璃体视网膜界面的可视化至关重要。在本研究中，我们评估了一种新型基于叶黄素的活性染料（LB-VD）对接受25G玻璃体切除术治疗特发性视网膜前膜（ERM）患者的玻璃体和后玻璃体膜进行选择性染色的效果。
对总共18例接受LB-VD辅助的ERM手术患者进行回顾性分析。外科医生完成了一份术后满意度问卷以评估玻璃体染色情况。在基线以及术后4个月和6个月收集最佳矫正视力（BCVA）、中心视网膜厚度（CRT）、眼压（IOP）和注视稳定性的数据。
LB-VD有效地对玻璃体和后玻璃体膜进行了染色，有助于关键的手术操作。术后4个月和6个月时，BCVA和CRT均有显著改善。具体而言，BCVA从基线时的0.60±0.29 LogMAR提高到4个月时的0.33±0.26 LogMAR（P = 0.004）以及6个月时的0.32±0.25 LogMAR（P = 0.003）。CRT从基线时的429（375 - 499）μm显著降低至4个月时的335（254 - 375）μm（P = 0.03）以及6个月时的323（240 - 356）μm（P = 0.01）。到6个月时，约95%的患者注视稳定性得到改善。未观察到IOP有显著变化。
LB-VD能清晰显示玻璃体和后玻璃体膜，从而有助于关键的玻璃体视网膜手术任务。这些发现表明LB-VD是目前玻璃体视网膜手术中使用的传统染料的一种有效且安全的替代品。
