Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.
School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Nutrients. 2022 Jun 27;14(13):2652. doi: 10.3390/nu14132652.
Vitamin D deficiency has become a widespread public health problem owing to its potential adverse health effects. Generally, the nutritional status of vitamin D depends on sunlight exposure and dietary or supplementary intake. However, recent studies have found that exercise can influence circulating 25(OH)D levels; although, the results have been inconclusive. In this review, we focused on the effect of exercise on circulating vitamin D metabolites and their possible mechanisms. We found that endurance exercise can significantly increase serum 25(OH)D levels in vitamin D-deficient people but has no significant effect on vitamin D-sufficient people. This benefit has not been observed with resistance training. Only chronic endurance exercise training can significantly increase serum 1,25(OH)D, and the effect may be sex-dependent. Exercise may influence 25(OH)D levels in the circulation by regulating either the vitamin D metabolites stored in tissues or the utilization by target tissues. The effects of exercise on 25(OH)D levels in the circulation may be dependent on many factors, such as the vitamin D nutritional status, exercise type and intensity, and sex. Therefore, further research on the effects and mechanisms of exercise on vitamin D metabolites is required.
维生素 D 缺乏症已成为一个广泛存在的公共卫生问题，因为它可能对健康产生不良影响。一般来说，维生素 D 的营养状况取决于阳光照射和饮食或补充摄入。然而，最近的研究发现，运动可以影响循环 25(OH)D 水平；尽管结果尚无定论。在这篇综述中，我们重点讨论了运动对循环维生素 D 代谢物的影响及其可能的机制。我们发现，耐力运动可以显著增加维生素 D 缺乏人群的血清 25(OH)D 水平，但对维生素 D 充足的人群没有显著影响。抗阻运动则没有观察到这种益处。只有慢性耐力运动训练才能显著增加血清 1,25(OH)D，其效果可能存在性别依赖性。运动可能通过调节组织中储存的维生素 D 代谢物或靶组织的利用来影响循环中 25(OH)D 水平。运动对循环中 25(OH)D 水平的影响可能取决于许多因素，如维生素 D 营养状况、运动类型和强度以及性别。因此，需要进一步研究运动对维生素 D 代谢物的影响和机制。
