Computational Neuroscience (CN) is an interdisciplinary field that combines neuroscience, mathematics, artificial intelligence, theoretical models and experimental data to understand how the brain works. It unravels the intricacies of the nervous system contributing significantly to cognitive science, neuroengineering and machine learning. CN importance in artificial intelligence and medical research remains underrepresented in Africa's academic landscape. This paper explores the current state of CN in Africa, the challenges hindering its integration, the emerging opportunities, and the evidence-based strategies for curriculum implementation. Capacity building, interdisciplinary collaboration, open science, theoretical neuroscience, development of local capacity, and leveraging international partnerships are emphasized.