Dundee J W
Postgrad Med J. 1985;61 Suppl 3:3-6.
Ideally one would like a water-soluble, non-irritant, rapidly-acting, smooth induction agent, with no antanalgesic action. Cardiovascular and respiratory depression should be minimal with normal dosage. Since these are unlikely to be achieved with a single drug, the combination of opioid and induction agent offers possibilities that should be explored. A slight delay in onset would not be a major obstacle, provided this is predictable, but the prime need is for a rapidly acting less toxic alternative to thiopentone.
理想情况下，人们希望有这样一种诱导剂：水溶性、无刺激性、起效迅速、作用平稳，且无抗镇痛作用。正常剂量下，其对心血管和呼吸系统的抑制作用应降至最低。由于单一药物不太可能实现这些要求，阿片类药物与诱导剂的联合使用提供了值得探索的可能性。只要起效延迟时间可预测，那么稍有延迟也不会成为主要障碍，但首要需求是找到一种起效迅速且毒性低于硫喷妥钠的替代药物。
