Oja S S, Korpi E R, Holopainen I, Kontro P
Prog Clin Biol Res. 1985;179:237-47.
Spontaneous taurine efflux from brain cells is strikingly slow and only moderately enhanced by either homo- or heteroexchange. A part of taurine release evoked by potassium depolarization from brain slices and synaptosomes is clearly calcium dependent when the enhancement of release--to a great extent from glial cells--induced by calcium-free media and calcium chelators is properly taken into account in evaluation. Sodium-free medium is the most effective means in provoking taurine efflux. It is suggested that normally the transmembrane sodium gradients aid in maintaining the high intracellular taurine concentrations.
来自脑细胞的牛磺酸自发外流非常缓慢，并且通过同向或异向交换仅适度增强。当在评估中适当考虑无钙培养基和钙螯合剂诱导的释放增强（在很大程度上来自神经胶质细胞）时，脑片和突触体中钾去极化引起的一部分牛磺酸释放明显依赖于钙。无钠培养基是引发牛磺酸外流的最有效手段。有人提出，正常情况下跨膜钠梯度有助于维持细胞内高浓度的牛磺酸。
