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Blood-brain barrier water exchange and paramagnetic susceptibility alterations during anti-amyloid therapy: preliminary MRI findings.

作者信息

Uchida Yuto, Kano Yuya, Kan Hirohito, Sakurai Keita, Morita Hideyasu, Akagawa Yoshihiro, Matsukawa Noriyuki, Oishi Kenichi

机构信息

Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 208 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA; Department of Neurology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.

Department of Neurology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan; Department of Neurology, Toyokawa City Hospital, 23, Noji, Yawata-cho, Toyokawa, Aichi 442-0857, Japan.

出版信息

J Prev Alzheimers Dis. 2025 Sep;12(8):100256. doi: 10.1016/j.tjpad.2025.100256. Epub 2025 Jun 30.

DOI:10.1016/j.tjpad.2025.100256
PMID:40592633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12413729/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c64/12413729/90e437d9af0f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c64/12413729/90e437d9af0f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c64/12413729/90e437d9af0f/gr1.jpg

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本文引用的文献

1
Quantitative susceptibility mapping for susceptibility source separation with adaptive relaxometric constant estimation (QSM-ARCS) from solely gradient-echo data.仅从梯度回波数据进行适应性弛豫常数估计的（QSM-ARCS）用于磁化率源分离的定量磁化率映射。
Neuroimage. 2024 Aug 1;296:120676. doi: 10.1016/j.neuroimage.2024.120676. Epub 2024 Jun 7.
2
Lecanemab in Early Alzheimer's Disease.早期阿尔茨海默病中的lecanemab
N Engl J Med. 2023 Jan 5;388(1):9-21. doi: 10.1056/NEJMoa2212948. Epub 2022 Nov 29.
3
dose associates with increased brain iron and β-amyloid via blood-brain barrier dysfunction.
剂量通过血脑屏障功能障碍与脑铁和β-淀粉样蛋白增加相关。
J Neurol Neurosurg Psychiatry. 2022 Apr 28. doi: 10.1136/jnnp-2021-328519.
4
Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways.脑淀粉样血管病与阿尔茨海默病——一种肽，两种途径。
Nat Rev Neurol. 2020 Jan;16(1):30-42. doi: 10.1038/s41582-019-0281-2. Epub 2019 Dec 11.
5
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.淀粉样蛋白相关成像异常在淀粉样蛋白修饰治疗试验中的研究：来自阿尔茨海默病协会研究圆桌工作组的建议。
Alzheimers Dement. 2011 Jul;7(4):367-85. doi: 10.1016/j.jalz.2011.05.2351.