Cao Xiyang, Fu Yuyang, Tao Yongsheng, Lu Qingquan
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, P. R. China.
Wuhan University Shenzhen Research Institute, Shenzhen, P. R. China.
Nat Commun. 2025 Jul 1;16(1):5686. doi: 10.1038/s41467-025-60230-5.
Electrocatalytic methods that facilitate the asymmetric reductive coupling of two π-components with complete control over regio-, stereo-, and enantioselectivity remain underexplored. Herein, we report a highly regio- and enantioselective cobaltaelectro-catalyzed alkyne-aldehyde coupling reaction, in which protons and electrons serve as the hydrogen source and reductant, respectively. Earth-abundant cobalt and air-stable (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline (QuinoxP*) are used as the catalyst and ligand, respectively. A series of enantioenriched allylic alcohols can be constructed with excellent regio- (>19:1), stereo- (>19:1 E:Z), and enantioselectivity (up to 98% ee).
能够完全控制区域选择性、立体选择性和对映选择性，促进两个π组分进行不对称还原偶联的电催化方法仍未得到充分探索。在此，我们报道了一种高度区域选择性和对映选择性的钴电催化炔烃-醛偶联反应，其中质子和电子分别作为氢源和还原剂。储量丰富的钴和空气稳定的(S,S)-2,3-双(叔丁基甲基膦基)喹喔啉(QuinoxP*)分别用作催化剂和配体。一系列对映体富集的烯丙醇能够以优异的区域选择性(>19:1)、立体选择性(>19:1 E:Z)和对映选择性(高达98% ee)构建而成。
