Gorinevsky Dimitry
Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
Sci Rep. 2025 Jul 1;15(1):20835. doi: 10.1038/s41598-025-02734-0.
Many Parkinson's Disease tremor behaviors that were considered hard to interpret can be explained by control systems modeling of mid-level motor control. The model in this paper includes stretch reflex loop with feedback delay and tonically controlled antagonist muscles. It also includes Basal Ganglia circuit that commands (schedules) gain changes in the reflex feedback loop. Computational analysis of the control systems model shows how the gain changes might turn the tremor on and off between pose maintenance and voluntary motion in the disease and normal state. The results might be useful for interpreting and tuning the effects of Parkinson's Disease treatments. They also provide new control systems engineering insight into mid-level motor control.
许多曾被认为难以解释的帕金森病震颤行为，都可以通过中级运动控制的控制系统建模来解释。本文中的模型包括具有反馈延迟的牵张反射回路和张力控制的拮抗肌。它还包括基底神经节回路，该回路控制（安排）反射反馈回路中的增益变化。控制系统模型的计算分析表明，在疾病和正常状态下，增益变化是如何在姿势维持和自主运动之间开启和关闭震颤的。这些结果可能有助于解释和调整帕金森病治疗的效果。它们还为中级运动控制提供了新的控制系统工程见解。
