Xu He, Si Chang
Department of Oncology Radiotherapy, First Affiliated Hospital of China Medical University, No. 210, Baitayi Street, Hunnan District, Shenyang, 110170, Liaoning Province, People's Republic of China.
Sci Rep. 2025 Jul 2;15(1):23100. doi: 10.1038/s41598-025-07822-9.
The aim of this study was to investigate the prevalence of thyroid nodule and its association with triglyceride-glucose index (TyG) in Western Liaoning Province of China. A cross-sectional survey was conducted in six counties under the jurisdiction of Huludao, Fuxin, and Chaoyang in Liaoning Province from 2019 to 2022. All the subjects who underwent thyroid B-ultrasound and related biochemical tests were recruited. TyG was calculated using fasting triglycerides and plasma glucose. A total of 2374 subjects were included, of which 583 (24.6%) were found to have thyroid nodules. The results of multivariate regression analysis indicated that a higher quartile of TyG was an independent risk factor for thyroid nodule. The results of subgroup analysis suggested that the above association was more explicit in younger subjects, non-smokers, highly educated or high-income groups, and non-iodine-deficient subjects. Similar findings were demonstrated in subjects with solitary or multiple thyroid nodules. Our study suggested for the first time that a higher TyG level is the risk factor for thyroid nodule, and the association between the two is more explicit in specific populations. It is recommended that people with high TyG levels should pay more attention to the regular screening of TN.
本研究旨在调查中国辽宁省西部甲状腺结节的患病率及其与甘油三酯-葡萄糖指数（TyG）的关系。2019年至2022年，在辽宁省葫芦岛、阜新和朝阳管辖的六个县进行了横断面调查。招募了所有接受甲状腺B超检查及相关生化检测的受试者。TyG通过空腹甘油三酯和血糖计算得出。共纳入2374名受试者，其中583名（24.6%）被发现患有甲状腺结节。多因素回归分析结果表明，TyG四分位数越高是甲状腺结节的独立危险因素。亚组分析结果提示，上述关联在年轻受试者、非吸烟者、高学历或高收入群体以及非碘缺乏受试者中更为明显。在单发或多发甲状腺结节患者中也得到了类似的结果。我们的研究首次表明，TyG水平升高是甲状腺结节的危险因素，且两者之间的关联在特定人群中更为明显。建议TyG水平高的人群应更加重视甲状腺结节的定期筛查。
