Sarteel A M, Merlen J F
Phlebologie. 1985 Jul-Sep;38(3):383-7.
Even though sclerotherapy is a method which, in careful and experienced hands, is entirely harmless, the assault on the venous endothelium can, nevertheless, precipitate incidents and accidents, which the authors enumerate briefly in order to pinpoint that of pigmentation. The authors consider that, although this is not certain, venous stasis is responsible for this, venous stasis causing erythrodiapedesis followed by the formation of haemosiderin and the increased activity of the dermic melanocytes, a process which is exacerbated by subjacent inflammation. An axon reflex releasing P substance (Van Euler and Gaddum) modulating the chemical influx on the endothelial receptors in the microcirculation. Prevention will be achieved by combatting the venous hypertension and stasis, and the formation of heamosiderin, melanoids, and the inflammatory process.
尽管硬化疗法在操作谨慎且经验丰富的医生手中是一种完全无害的方法，但对静脉内皮的刺激仍可能引发一些事件和意外情况，作者简要列举了这些情况以便明确色素沉着问题。作者认为，尽管尚不确定，但静脉淤滞是其原因，静脉淤滞导致红细胞渗出，随后形成含铁血黄素并使真皮黑素细胞活性增加，而下方的炎症会加剧这一过程。一种轴突反射释放P物质（范·欧拉和加德姆），调节微循环中内皮受体上的化学物质流入。通过对抗静脉高压和淤滞以及含铁血黄素、黑素类物质的形成和炎症过程来实现预防。
