Merlen J F, Coget J, Sarteel A M
Phlebologie. 1983 Oct-Dec;36(4):307-14.
Local pigmentations can occur in the course of venous diseases and are said to be secondary to venous stasis and due to blood pigment. Most often, the pigment is haemosiderin and more rarely melenin pigments. Haemosiderin is a result of dermal biligenesis of extravasated red blood cells, the erythrodiapedesis being due to alterations in the vessel wall. Melanin pigments remain a mystery. Meaanoid may stimulate dermal melanocytes more than the true melanocytes of neural origin which have migrated to the epidermis. Above all, the problem is dominated by stasis and its microvascular and tissue consequences. The pigmentation is part of the "microangiopathy of stasis", as are the pigmentations occurring after therapeutic sclerosis.
局部色素沉着可发生于静脉疾病过程中,据说是继发于静脉淤滞且由血液色素引起。大多数情况下,色素是含铁血黄素,较少见的是黑色素。含铁血黄素是血管外红细胞真皮内双生成的结果,红细胞渗出是由于血管壁改变所致。黑色素仍然是个谜。类黑素可能比迁移至表皮的真正神经源性黑素细胞更能刺激真皮黑素细胞。最重要的是,该问题主要由淤滞及其微血管和组织后果所主导。色素沉着是“淤滞性微血管病”的一部分,治疗性硬化后出现的色素沉着也是如此。