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核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

一种皮肤界面三维闭环传感与治疗电子伤口绷带。

A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage.

作者信息

Huang Xingcan, Zhang Qiang, Yang Yawen, Chow Lung, Ma Jie, Xu Guoqiang, Guo Fang, He Xinxin, Li Zhiyuan, Zhao Guangyao, Su Jingyou, Guo Guihuan, Wang Jiachen, Jiao Yanli, Gao Zhan, Li Jiyu, Zhou Jingkun, Yiu Chun Ki, Li Jian, Chen Yi, Wu Pengcheng, Yao Kuanming, Liu Yiming, Li Dengfeng, Zhang Binbin, Chu Hongwei, Hu Yue, Huang Ya, Chen Zhenlin, Ren Kangning, Fang Bo, Yang Rungong, Li Heng, Tao Xiaoming, Ma Xiaohui, Yu Xinge

机构信息

Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong, China.

Institute of Digital Medicine, City University of Hong Kong, Kowloon, Hong Kong, China.

出版信息

Nat Commun. 2025 Jul 1;16(1):5782. doi: 10.1038/s41467-025-61261-8.

DOI:10.1038/s41467-025-61261-8
PMID:40593825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12218315/
Abstract

Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.

摘要

慢性伤口愈合是一个复杂且长期存在的问题，多年来一直是全球主要且关键的临床关注点。数字伤口敷料的最新进展为解决该问题开辟了新的可能性。在此，我们报告一种用于智能伤口管理的无电池、完全可渗透、皮肤粘附性、可拉伸的电子伤口绷带（iSAFE）。这种电子绷带在多个特性方面表现出卓越性能，并且可以贴合在皮肤伤口上。此外，iSAFE能够原位准确评估伤口状况，从而自适应地进行局部药物释放。动物的体外和体内研究结果证明了伤口监测、促进伤口愈合以及智能闭环伤口管理的有效性。对18至95岁患有各种类型伤口的患者进行了临床试验。这些结果均表明所报道的伤口监测和管理技术具有独特性和通用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/2c69edf59dfe/41467_2025_61261_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/8915902c19bd/41467_2025_61261_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/d0cd82e944d5/41467_2025_61261_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/881e7c8ab974/41467_2025_61261_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/44b872a104db/41467_2025_61261_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/590a0a249087/41467_2025_61261_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/c87c37ea7513/41467_2025_61261_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/2c69edf59dfe/41467_2025_61261_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/8915902c19bd/41467_2025_61261_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/d0cd82e944d5/41467_2025_61261_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/881e7c8ab974/41467_2025_61261_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/44b872a104db/41467_2025_61261_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/590a0a249087/41467_2025_61261_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/c87c37ea7513/41467_2025_61261_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9f0/12218315/2c69edf59dfe/41467_2025_61261_Fig7_HTML.jpg

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[1]
A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage.

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[8]
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[9]
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[10]
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本文引用的文献

[1]
Immunomodulatory Biomaterials: Tailoring Surface Properties to Mitigate Foreign Body Reaction and Enhance Tissue Regeneration.

Adv Healthc Mater. 2024-11

[2]
Wearable bio-adhesive metal detector array (BioMDA) for spinal implants.

Nat Commun. 2024-9-6

[3]
A three-dimensional liquid diode for soft, integrated permeable electronics.

Nature. 2024-4

[4]
First magnetic particle imaging to assess pulmonary vascular leakage in vivo in the acutely injured and fibrotic lung.

Bioeng Transl Med. 2023-11-29

[5]
Wearable and battery-free wound dressing system for wireless and early sepsis diagnosis.

Bioeng Transl Med. 2023-2-1

[6]
Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid.

ACS Appl Mater Interfaces. 2023-10-4

[7]
A Biomimetic Adhesive and Robust Janus Patch with Anti-Oxidative, Anti-Inflammatory, and Anti-Bacterial Activities for Tendon Repair.

ACS Nano. 2023-9-12

[8]
Thin, soft, wearable system for continuous wireless monitoring of artery blood pressure.

Nat Commun. 2023-8-17

[9]
UV-polymerizable methacrylated gelatin (GelMA)-based hydrogel containing tannic acids for wound healing.

Drug Deliv Transl Res. 2023-12

[10]
A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds.

Sci Adv. 2023-3-24

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