Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Science, Tehran, Iran.
Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Adv Healthc Mater. 2024 Nov;13(29):e2401253. doi: 10.1002/adhm.202401253. Epub 2024 Oct 6.
The immune cells have demonstrated the ability to promote tissue repair by removing debris, breaking down the extracellular matrix, and regulating cytokine secretion profile. If the behavior of immune cells is not well directed, chronic inflammation and foreign body reaction (FBR) will lead to scar formation and loss of biomaterial functionality. The immunologic response toward tissue repair or chronic inflammation after injury and implantation can be modulated by manipulating the surface properties of biomaterials. Tailoring surface properties of biomaterials enables the regulation of immune cell fate such as adhesion, proliferation, recruitment, polarization, and cytokine secretion profile. This review begins with an overview of the role of immune cells in tissue healing and their interactions with biomaterials. It then discusses how the surface properties of biomaterials influence immune cell behavior. The core focus is reviewing surface modification methods to create innovative materials that reduce foreign body reactions and enhance tissue repair and regeneration by modulating immune cell activities. The review concludes with insights into future advancements in surface modification techniques and the associated challenges.
免疫细胞已证明具有通过清除碎片、分解细胞外基质和调节细胞因子分泌谱来促进组织修复的能力。如果免疫细胞的行为不能很好地引导，慢性炎症和异物反应 (FBR) 将导致瘢痕形成和生物材料功能丧失。通过操纵生物材料的表面特性，可以调节组织修复或损伤和植入后的慢性炎症的免疫反应。定制生物材料的表面特性可以调节免疫细胞的命运，如黏附、增殖、募集、极化和细胞因子分泌谱。本综述首先概述了免疫细胞在组织愈合中的作用及其与生物材料的相互作用。然后讨论了生物材料的表面特性如何影响免疫细胞的行为。核心重点是回顾表面改性方法，以创建创新材料，通过调节免疫细胞的活性来减少异物反应并增强组织修复和再生。该综述最后对表面改性技术的未来进展和相关挑战提出了见解。
