Taylor I L, Garcia R, Elashoff J
Physiol Behav. 1985 Jun;34(6):957-61. doi: 10.1016/0031-9384(85)90019-8.
Cholecystokinin, bombesin and pancreatic polypeptide are all reported to induce satiety in rodents. To test the hypothesis that cholecystokinin and bombesin induce satiety through release of pancreatic polypeptide, we compared the satiety inducing properties of each peptide in rats trained to eat a liquid diet (Magnacal). Studies were repeated after transabdominal truncal vagotomy (n = 8) or sham operation (n = 8). Peptides were given by intraperitoneal injection, and the volume of Magnacal ingested over a 2 hr period measured. After the injection of saline, unoperated rats (n = 16) ingested 30 +/- 2.3 ml of Magnacal. Caerulein (9 nmol/kg) and bombesin (27 nmol/kg) significantly inhibited food intake to 8 +/- 2.5 ml and 20 +/- 2.1 ml respectively. In contrast pancreatic polypeptide (27 nmol/kg) had no significant effect on food intake. Both caerulein and bombesin retained the ability to reduce food intake after vagotomy although the effects of caerulein were somewhat blunted. No significant changes in serum pancreatic poly peptide concentrations were observed after either the caerulein or bombesin injection. As both peptides release pancreatic polypeptide in higher mammals, species differences in release mechanisms appear to exist. We would conclude that caerulein and bombesin induced satiety is independent of pancreatic polypeptide release and that the weight loss induced by pancreatic polypeptide in obese rodents is unlikely to be due to induction of satiety.
据报道，胆囊收缩素、蛙皮素和胰多肽均可诱导啮齿动物产生饱腹感。为了验证胆囊收缩素和蛙皮素通过释放胰多肽来诱导饱腹感这一假说，我们比较了每种肽在训练以流食（Magnacal）为食的大鼠中的饱腹感诱导特性。在经腹行迷走神经干切断术（n = 8）或假手术（n = 8）后重复进行研究。通过腹腔注射给予肽，并测量2小时内摄入的Magnacal量。注射生理盐水后，未手术的大鼠（n = 16）摄入30±2.3 ml的Magnacal。蛙皮素（9 nmol/kg）和蛙皮素（27 nmol/kg）分别显著抑制食物摄入量至8±2.5 ml和20±2.1 ml。相比之下，胰多肽（27 nmol/kg）对食物摄入量没有显著影响。迷走神经切断术后，蛙皮素和蛙皮素均保留了减少食物摄入量的能力，尽管蛙皮素的作用有所减弱。注射蛙皮素或蛙皮素后，血清胰多肽浓度均未观察到显著变化。由于这两种肽在高等哺乳动物中均释放胰多肽，因此释放机制似乎存在种属差异。我们得出结论，蛙皮素和蛙皮素诱导的饱腹感与胰多肽释放无关，肥胖啮齿动物中胰多肽诱导的体重减轻不太可能是由于诱导饱腹感所致。
