Taylor I L, Garcia R
Am J Physiol. 1985 Mar;248(3 Pt 1):G277-80. doi: 10.1152/ajpgi.1985.248.3.G277.
Congenitally obese mice are hyperphagic, suggesting that their obesity is secondary to defects in normal satiety mechanisms. The present study compares the effects of caerulein, bombesin, and pancreatic polypeptide (three equimolar doses each of 3, 9, and 27 nmol/kg) on food intake in 10 pairs of lean and obese mice. After the intraperitoneal injection of saline, obese mice eat 240% more of a liquid meal (Magnacal) than their lean littermates (P less than 0.01). All three doses of caerulein significantly inhibited food intake in both obese and lean mice. Although the highest dose of bombesin significantly decreased food intake in both obese and lean mice, the lowest dose was only effective in obese mice. In contrast, none of these doses of pancreatic polypeptide had a significant effect on food intake in either lean or obese mice. A dose of bovine pancreatic polypeptide of 200 nmol/kg was required to significantly reduce food intake in lean and obese mice. This study demonstrates that obese mice respond to satiety signals and may even be more sensitive than their lean littermates to some messengers. In addition, the previously described reversal of this obesity syndrome by pancreatic polypeptide in doses of approximately 2.5 and 25 nmol X kg-1 X day-1 is unlikely to be due to effects of this peptide on food intake.
先天性肥胖小鼠食欲亢进，这表明它们的肥胖是正常饱腹感机制缺陷的继发结果。本研究比较了蛙皮素、铃蟾肽和胰多肽（三种等摩尔剂量，分别为3、9和27 nmol/kg）对10对瘦小鼠和肥胖小鼠食物摄入量的影响。腹腔注射生理盐水后，肥胖小鼠比同窝瘦小鼠多摄入240%的流质食物（Magnacal）（P<0.01）。所有三种剂量的蛙皮素均显著抑制肥胖小鼠和瘦小鼠的食物摄入量。虽然最高剂量的铃蟾肽显著降低了肥胖小鼠和瘦小鼠的食物摄入量，但最低剂量仅对肥胖小鼠有效。相比之下，这些剂量的胰多肽对瘦小鼠或肥胖小鼠的食物摄入量均无显著影响。需要200 nmol/kg的牛胰多肽剂量才能显著降低瘦小鼠和肥胖小鼠的食物摄入量。本研究表明，肥胖小鼠对饱腹感信号有反应，甚至可能比同窝瘦小鼠对某些信使更敏感。此外，先前描述的胰多肽以约2.5和25 nmol·kg-1·d-1的剂量逆转这种肥胖综合征的现象不太可能是由于该肽对食物摄入量的影响。
