Liu Shuo, Yang Shuo, Wang Chen, Li Jiarui, Wang Lei
School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300130, China.
State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin, 300130, China.
NPJ Parkinsons Dis. 2025 Jul 1;11(1):191. doi: 10.1038/s41531-025-01054-4.
Intermittent theta burst stimulation (iTBS) may have higher efficiency and stronger excitatory effects compared to conventional high-frequency repetitive transcranial magnetic stimulation (HF-rTMS). To evaluate the therapeutic effects of the two modalities, we compared the differences in spatiotemporal variability of electroencephalography (EEG) microstate-based brain networks between 51 PD patients and 21 healthy controls. The 51 PD patients were randomly assigned to either iTBS or 10Hz-rTMS groups to compare pre- and post-treatment clinical assessment results and spatiotemporal variability changes. Baseline measurements showed significant differences in spatiotemporal variability between PD patients and healthy controls, with certain brain regions demonstrating significant correlations between spatiotemporal variability and clinical assessment results. Both treatment groups exhibited significant improvements in all clinical outcomes compared to baseline. The iTBS group showed post-treatment changes involving more brain regions in spatiotemporal variability. This study demonstrates that compared to 10Hz-rTMS, iTBS can reduce treatment time while providing superior improvement in functional brain connectivity for PD patients.
与传统高频重复经颅磁刺激（HF-rTMS）相比，间歇性θ波爆发刺激（iTBS）可能具有更高的效率和更强的兴奋作用。为了评估这两种治疗方式的疗效，我们比较了51例帕金森病（PD）患者和21名健康对照者基于脑电图（EEG）微状态的脑网络时空变异性差异。将51例PD患者随机分为iTBS组或10Hz-rTMS组，以比较治疗前后的临床评估结果和时空变异性变化。基线测量显示，PD患者与健康对照者在时空变异性方面存在显著差异，某些脑区的时空变异性与临床评估结果之间存在显著相关性。与基线相比，两个治疗组的所有临床结局均有显著改善。iTBS组治疗后时空变异性涉及的脑区更多。本研究表明，与10Hz-rTMS相比，iTBS可以缩短治疗时间，同时为PD患者提供更好的脑功能连接改善。
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